Journal article
Requirement of the MASH-1 transcription factor for neuroendocrine differentiation of thyroid C cells
Journal of neurobiology, Vol.34(2), pp.126-134
02/05/1998
DOI: 10.1002/(SICI)1097-4695(19980205)34:2<126::AID-NEU3>3.0.CO;2-4
PMID: 9468384
Abstract
Thyroid C cells are neural crestâ€derived neuroendocrine cells that can acquire features similar to serotonergic neurons. Based on developmental and phenotypic markers, we have previously proposed that C cells and serotonergic enteric neurons arise from a common sympathoadrenal progenitor. In this report, we genetically examined this relationship using mice lacking the mammalian achaeteâ€scute homologue 1 (MASHâ€1) transcription factor, since MASHâ€1 has recently been shown to be required for differentiation of serotonergic enteric neurons. We found that MASHâ€1 knockout mice have a greatly reduced number of C cells based on the lack of calcitonin and serotonin immunoreactivity. In contrast, calcitonin and serotonin were still expressed in cultured mature C cells that no longer express MASHâ€1, demonstrating that MASHâ€1 is not directly required for the expression of these two markers. Hence, MASHâ€1 is required to establish the Câ€cell phenotype and supports the model that C cells lie in the neuronal differentiation pathway of the sympathoadrenal neural crest. © 1998 John Wiley & Sons, Inc. J Neurobiol 34: 126–134, 1998
Details
- Title: Subtitle
- Requirement of the MASH-1 transcription factor for neuroendocrine differentiation of thyroid C cells
- Creators
- Thomas M LaniganShannon K DeRaadAndrew F Russo
- Resource Type
- Journal article
- Publication Details
- Journal of neurobiology, Vol.34(2), pp.126-134
- DOI
- 10.1002/(SICI)1097-4695(19980205)34:2<126::AID-NEU3>3.0.CO;2-4
- PMID
- 9468384
- NLM abbreviation
- J Neurobiol
- ISSN
- 0022-3034
- eISSN
- 1097-4695
- Publisher
- John Wiley & Sons, Inc; New York
- Number of pages
- 9
- Grant note
- NIH (HD25969) Diabetes and Endocrinology Center (DK25295)
- Language
- English
- Date published
- 02/05/1998
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984020622802771
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