Journal article
Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop
JACC. Basic to translational science, Vol.7(3), pp.265-293
03/01/2022
DOI: 10.1016/j.jacbts.2021.11.003
PMCID: PMC8993767
PMID: 35411324
Abstract
This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed. (J Am Coll Cardiol Basic Trans Science 2022;7:265-293 ) (c) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Details
- Title: Subtitle
- Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop
- Creators
- Reena Mehra - Case Western Reserve UniversityOlga A. Tjurmina - National Heart Lung and Blood InstituteOlujimi A. Ajijola - University of California, Los AngelesRishi Arora - Northwestern UniversityDonald C. Bolser - University of FloridaMark W. Chapleau - Roy J. and Lucille A. Carver College of MedicinePeng-Sheng Chen - Cedars-Sinai Medical CenterColleen E. Clancy - University of California, DavisBrian P. Delisle - University of KentuckyMichael R. Gold - Medical University of South CarolinaJeffrey J. Goldberger - University of MiamiDavid S. Goldstein - National Institute of Neurological Disorders and StrokeBeth A. Habecker - Oregon Health & Science UniversityM. Louis Handoko - Amsterdam University Medical CentersRobert Harvey - University of Nevada RenoJames P. Hummel - Yale UniversityThomas Hund - The Ohio State UniversityChristian Meyer - University of Düsseldorf, Germany, Düsseldorf, GermanySusan Redline - Harvard UniversityCrystal M. Ripplinger - University of California, DavisMarc A. Simon - Univ Pittsburgh, Med Ctr, Pittsburgh, PA USAVirend K. Somers - Mayo Clin, Rochester, MN USAStavros Stavrakis - Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USAThomas Taylor-Clark - The Ohio State UniversityBradley Joel Undem - Johns Hopkins Univ, Baltimore, MD USARichard L. Verrier - Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USAIrving H. Zucker - Univ Nebraska Med Ctr, Omaha, NE USAGeorge Sopko - NHLBI, Bldg 10, Bethesda, MD 20892 USAKalyanam Shivkumar
- Resource Type
- Journal article
- Publication Details
- JACC. Basic to translational science, Vol.7(3), pp.265-293
- DOI
- 10.1016/j.jacbts.2021.11.003
- PMID
- 35411324
- PMCID
- PMC8993767
- NLM abbreviation
- JACC Basic Transl Sci
- ISSN
- 2452-302X
- eISSN
- 2452-302X
- Publisher
- Elsevier
- Number of pages
- 29
- Grant note
- 2 020T058 / Dutch Heart Foundation; Netherlands Heart Foundation 20IPA35320141 / American Heart Association Allen Chair in Cardiology Research, Cedars-Sinai Medical Center Department of Physiology and Membrane Biology Research Partnership Fund Quin American Heart Association Strategically Focused Research Networks Atrial Fibrillation Center Novartis Jazz Pharmaceuticals Oracle cloud forresearch allocation Vifor Pharma National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01 HL140061; R01 HL125881 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Sorrento Therapeutics, Inc. Boston Scientific National Institutes of Health (NIH) Office of the Director; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA InCarda Therapeutics 18SFRN34170013 / American Heart Association AHA; American Heart Association Boehringer Ingelheim
- Language
- English
- Date published
- 03/01/2022
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984297598202771
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