Journal article
Research Recommendations for Selected IARC-Classified Agents
Environmental health perspectives, Vol.118(10), pp.1355-1362
10/2010
DOI: 10.1289/ehp.0901828
PMCID: PMC2957912
PMID: 20562050
Abstract
Objectives
There are some common occupational agents and exposure circumstances for which evidence of carcinogenicity is substantial but not yet conclusive for humans. Our objectives were to identify research gaps and needs for 20 agents prioritized for review based on evidence of widespread human exposures and potential carcinogenicity in animals or humans.
Data sources
For each chemical agent (or category of agents), a systematic review was conducted of new data published since the most recent pertinent International Agency for Research on Cancer (IARC) Monograph meeting on that agent.
Data extraction
Reviewers were charged with identifying data gaps and general and specific approaches to address them, focusing on research that would be important in resolving classification uncertainties. An expert meeting brought reviewers together to discuss each agent and the identified data gaps and approaches.
Data synthesis
Several overarching issues were identified that pertained to multiple agents; these included the importance of recognizing that carcinogenic agents can act through multiple toxicity pathways and mechanisms, including epigenetic mechanisms, oxidative stress, and immuno- and hormonal modulation.
Conclusions
Studies in occupational populations provide important opportunities to understand the mechanisms through which exogenous agents cause cancer and intervene to prevent human exposure and/or prevent or detect cancer among those already exposed. Scientific developments are likely to increase the challenges and complexities of carcinogen testing and evaluation in the future, and epidemiologic studies will be particularly critical to inform carcinogen classification and risk assessment processes.
Details
- Title: Subtitle
- Research Recommendations for Selected IARC-Classified Agents
- Creators
- Elizabeth M Ward - California Environmental Protection Agency, Oakland, California, USAPaul A Schulte - California Environmental Protection Agency, Oakland, California, USAKurt Straif - California Environmental Protection Agency, Oakland, California, USANancy B Hopf - California Environmental Protection Agency, Oakland, California, USAJane C Caldwell - California Environmental Protection Agency, Oakland, California, USATania Carreón - California Environmental Protection Agency, Oakland, California, USADavid M DeMarini - California Environmental Protection Agency, Oakland, California, USABruce A Fowler - California Environmental Protection Agency, Oakland, California, USABernard D Goldstein - California Environmental Protection Agency, Oakland, California, USAKari Hemminki - California Environmental Protection Agency, Oakland, California, USACynthia J Hines - California Environmental Protection Agency, Oakland, California, USAKirsti Husgafvel Pursiainen - California Environmental Protection Agency, Oakland, California, USAEileen Kuempel - California Environmental Protection Agency, Oakland, California, USAJoellen Lewtas - California Environmental Protection Agency, Oakland, California, USARuth M Lunn - California Environmental Protection Agency, Oakland, California, USAElsebeth Lynge - California Environmental Protection Agency, Oakland, California, USADamien M McElvenny - California Environmental Protection Agency, Oakland, California, USAHartwig Muhle - California Environmental Protection Agency, Oakland, California, USATamie Nakajima - California Environmental Protection Agency, Oakland, California, USALarry W Robertson - California Environmental Protection Agency, Oakland, California, USANathaniel Rothman - California Environmental Protection Agency, Oakland, California, USAAvima M Ruder - California Environmental Protection Agency, Oakland, California, USAMary K Schubauer-Berigan - California Environmental Protection Agency, Oakland, California, USAJack Siemiatycki - California Environmental Protection Agency, Oakland, California, USADebra Silverman - California Environmental Protection Agency, Oakland, California, USAMartyn T Smith - California Environmental Protection Agency, Oakland, California, USATom Sorahan - California Environmental Protection Agency, Oakland, California, USAKyle Steenland - California Environmental Protection Agency, Oakland, California, USARichard G Stevens - California Environmental Protection Agency, Oakland, California, USAPaolo Vineis - California Environmental Protection Agency, Oakland, California, USAShelia Hoar Zahm - California Environmental Protection Agency, Oakland, California, USALauren Zeise - California Environmental Protection Agency, Oakland, California, USAVincent J Cogliano - California Environmental Protection Agency, Oakland, California, USA
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.118(10), pp.1355-1362
- Publisher
- National Institute of Environmental Health Sciences
- DOI
- 10.1289/ehp.0901828
- PMID
- 20562050
- PMCID
- PMC2957912
- ISSN
- 0091-6765
- eISSN
- 1552-9924
- Language
- English
- Date published
- 10/2010
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002364702771
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