Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats

Kristi L Helke; David K Meyerholz; Amanda P Beck; Eric R Burrough; Rachel J Derscheid; Christiane Löhr; Elizabeth F McInnes; Cheryl L Scudamore; Cory F Brayton

doi:10.1093/ilar/ilab005

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Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats

Kristi L Helke, David K Meyerholz, Amanda P Beck, Eric R Burrough, Rachel J Derscheid, Christiane Löhr, Elizabeth F McInnes, Cheryl L Scudamore and Cory F Brayton

ILAR journal, Vol.62(1-2), pp.133-168

03/13/2021

DOI: 10.1093/ilar/ilab005

PMID: 33712827

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Abstract

Abstract Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge not only of the processes/diseases being studied but also awareness of spontaneous conditions and background lesions in the model that can influence or even confound the study results. Species, breed/stock, sex, age, anatomy, physiology, diseases (noninfectious and infectious), and neoplastic processes are model features that can impact the results as well as study interpretation. Here, we review these features in several common laboratory animal species, including ferret, dog (beagle), pig, sheep, and goats.

Details

Title: Subtitle: Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats
Creators: Kristi L Helke - Medical University of South Carolina
David K Meyerholz - University of Iowa
Amanda P Beck - Albert Einstein College of Medicine
Eric R Burrough - Iowa State University
Rachel J Derscheid - Iowa State University
Christiane Löhr - Oregon State University
Elizabeth F McInnes - Syngenta
Cheryl L Scudamore - ExePathology, Pathologist at ExePathology, Exmouth, Devon, United Kingdom.
Cory F Brayton - Johns Hopkins University School of Medicine
Resource Type: Journal article
Publication Details: ILAR journal, Vol.62(1-2), pp.133-168
DOI: 10.1093/ilar/ilab005
PMID: 33712827
NLM abbreviation: ILAR J
ISSN: 1084-2020
eISSN: 1930-6180
Language: English
Date published: 03/13/2021
Academic Unit: Pathology
Record Identifier: 9984201255002771

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