Journal article
Research updates in cystic fibrosis related diabetes: Understanding pathophysiology, expanding animal and human islet models, and advancing clinical and translational research
Journal of cystic fibrosis
04/04/2026
DOI: 10.1016/j.jcf.2026.03.021
PMID: 41936497
Abstract
In 2024–2025, the Cystic Fibrosis Foundation (US) and Cystic Fibrosis Trust (UK) hosted an International CFRD Consortium round-table webinar series for basic science, translational, and clinical researchers with the goal of sharpening mechanistic understanding of CFRD pathogenesis and prioritizing therapeutic development. This review summarizes the research priorities identified in the International CFRD Consortium, including (i) further investigation into the role of pancreatic fibrosis, vascular abnormalities, and α-cell dysfunction in the development of CFRD; (ii) the creation and refinement of novel animal and human cell- and tissue-based models to understand the complex interplay of exocrine and endocrine cells in the CF pancreas; (iii) development and validation of circulating and imaging biomarkers, together with dynamic glucose testing to explore β-cell function and kinetics in people with CF across the dysglycemia spectrum; and (iv) prospective clinical studies to guide CFRD treatment options and investigate the changing landscape of aging, increasing prevalence of obesity and diabetes and their complications in the era of cystic fibrosis transmembrane conductance regulator (CFTR) modulators. Collectively, these priorities aim to accelerate transition from mechanism to intervention and expand evidence-based care for people with CF at risk of, or living with, CFRD.
Details
- Title: Subtitle
- Research updates in cystic fibrosis related diabetes: Understanding pathophysiology, expanding animal and human islet models, and advancing clinical and translational research
- Creators
- Melissa S. Putman - Massachusetts General HospitalRebecca L. Hull-Meichle - University of AlbertaShafagh A. Waters - UNSW SydneyKatherine Tuggle - Cystic Fibrosis FoundationPaula Sommer - Cystic Fibrosis TrustRebecca Conway - Newcastle UniversityLee A. Borthwick - Newcastle UniversityJakob G. Knudsen - University of CopenhagenE.Danielle Dean - Vanderbilt University Medical CenterSarah A. Stanley - Icahn School of Medicine at Mount SinaiXingshen Sun - University of Alabama at BirminghamJohn F. Engelhardt - University of Alabama at BirminghamShih-Hsing Leir - Case Western Reserve UniversityLena Eliasson - Lund UniversityBibi Uhre Nielsen - Copenhagen University HospitalDarko Stefanovski - University of PennsylvaniaAmanda Brennan - Manchester University NHS Foundation TrustCharlotte K. Boughton - University of CambridgeAndrea Kelly - Children's Hospital of PhiladelphiaAmir Moheet - University of MinnesotaJames A.M. Shaw - Newcastle University
- Resource Type
- Journal article
- Publication Details
- Journal of cystic fibrosis
- DOI
- 10.1016/j.jcf.2026.03.021
- PMID
- 41936497
- NLM abbreviation
- J Cyst Fibros
- ISSN
- 1569-1993
- eISSN
- 1873-5010
- Publisher
- Elsevier B.V
- Language
- English
- Electronic publication date
- 04/04/2026
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9985152241602771
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