Journal article
Residential radon-222 exposure and lung cancer: exposure assessment methodology
Journal of exposure analysis and environmental epidemiology, Vol.6(2), pp.181-195
04/1996
PMID: 8792296
Abstract
Although occupational epidemiological studies and animal experimentation provide strong evidence that radon-222 (222Rn) progeny exposure causes lung cancer, residential epidemiological studies have not confirmed this association. Past residential epidemiological studies have yielded contradictory findings. Exposure misclassification has seriously compromised the ability of these studies to detect whether an association exists between 222Rn exposure and lung cancer. Misclassification of 222Rn exposure has arisen primarily from: 1) detector measurement error; 2) failure to consider temporal and spatial 222Rn variations within a home; 3) missing data from previously occupied homes that currently are inaccessible; 4) failure to link 222Rn concentrations with subject mobility; and 5) measuring 222Rn gas concentration as a surrogate for 222Rn progeny exposure. This paper examines these methodological dosimetry problems and addresses how we are accounting for them in an ongoing, population-based, case-control study of 222Rn and lung cancer in Iowa.
Details
- Title: Subtitle
- Residential radon-222 exposure and lung cancer: exposure assessment methodology
- Creators
- R W Field - Department of Preventive Medicine and Environmental Health, College of Medicine, University of Iowa, Iowa City 52242-5000, USAD J SteckC F LynchC P BrusJ S NeubergerB C Kross
- Resource Type
- Journal article
- Publication Details
- Journal of exposure analysis and environmental epidemiology, Vol.6(2), pp.181-195
- PMID
- 8792296
- ISSN
- 1053-4245
- eISSN
- 1476-5519
- Grant note
- ES05653 / NIEHS NIH HHS
- Language
- English
- Date published
- 04/1996
- Academic Unit
- Occupational and Environmental Health; Epidemiology
- Record Identifier
- 9984216736302771
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