Journal article
Residual Hair Cell Responses in Electric-Acoustic Stimulation Cochlear Implant Users with Complete Loss of Acoustic Hearing After Implantation
Journal of the Association for Research in Otolaryngology, Vol.22(2), pp.161-176
04/2021
DOI: 10.1007/s10162-021-00785-4
PMCID: PMC7943691
PMID: 33538936
Abstract
Changes in cochlear implant (CI) design and surgical techniques have enabled the preservation of residual acoustic hearing in the implanted ear. While most Nucleus Hybrid L24 CI users retain significant acoustic hearing years after surgery, 6-17 % experience a complete loss of acoustic hearing (Roland et al. Laryngoscope. 126(1):175-81. (2016), Laryngoscope. 128(8):1939-1945 (2018); Scheperle et al. Hear Res. 350:45-57 (2017)). Electrocochleography (ECoG) enables non-invasive monitoring of peripheral auditory function and may provide insight into the pathophysiology of hearing loss. The ECoG response is evoked using an acoustic stimulus and includes contributions from the hair cells (cochlear microphonic-CM) as well as the auditory nerve (auditory nerve neurophonic-ANN). Seven Hybrid L24 CI users with complete loss of residual hearing months after surgery underwent ECoG measures before and after loss of hearing. While significant reductions in CMs were evident after hearing loss, all participants had measurable CMs despite having no measurable acoustic hearing. None retained measurable ANNs. Given histological data suggesting stable hair cell and neural counts after hearing loss (e.g., Quesnel et al. Hear Res. 333:225-234. (2016)), the loss of ECoG and audiometric hearing may reflect reduced synaptic input. This is consistent with the theory that residual CM responses coupled with little to no ANN responses reflect a "disconnect" between hair cells and auditory nerve fibers (Fontenot et al. Ear Hear. 40(3):577-591. 2019). This "disconnection" may prevent proper encoding of auditory stimulation at higher auditory pathways, leading to a lack of audiometric responses, even in the presence of viable cochlear hair cells.
Details
- Title: Subtitle
- Residual Hair Cell Responses in Electric-Acoustic Stimulation Cochlear Implant Users with Complete Loss of Acoustic Hearing After Implantation
- Creators
- Viral D Tejani - Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, USA. viral-tejani@uiowa.eduJeong-Seo Kim - Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, USAJacob J Oleson - Department of Biostatistics, University of Iowa, Iowa City, IA, USAPaul J Abbas - Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, USACarolyn J Brown - Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, USAMarlan R Hansen - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USABruce J Gantz - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of the Association for Research in Otolaryngology, Vol.22(2), pp.161-176
- DOI
- 10.1007/s10162-021-00785-4
- PMID
- 33538936
- PMCID
- PMC7943691
- ISSN
- 1525-3961
- eISSN
- 1438-7573
- Grant note
- P50 DC 00242 / NIDCD NIH HHS
- Language
- English
- Date published
- 04/2021
- Academic Unit
- Communication Sciences and Disorders; Molecular Physiology and Biophysics; Biostatistics; Neurosurgery; Otolaryngology
- Record Identifier
- 9984211770102771
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