Journal article
Residual naming after damage to the left temporal pole: a PET activation study
NeuroImage (Orlando, Fla.), Vol.19(3), pp.846-860
2003
DOI: 10.1016/S1053-8119(03)00109-5
PMID: 12880813
Abstract
Normal subjects activate the left temporal polar cortex when they name persons, and subjects with damage to the left temporal pole due to left anterior temporal lobectomy are impaired in the retrieval of the proper names of persons. Eight such subjects were studied in a PET activation experiment to address the neural systems supporting their residual naming. We hypothesized that there would be increased activity, relative to normal controls, in the surround of the damaged region, the homologous right temporal pole, or both. Neither the group nor individual target subjects showed significantly increased activity in the lesion surround or in the right temporal pole. Several other regions that are activated by normals during the retrieval of the proper names of persons and which were undamaged in the target subjects (left anterior superior temporal sulcus, mesial frontal cortex, and anterior cingulate) were nevertheless significantly less activated by the target subjects, a finding that suggests that damage to the left temporal pole alters the function of a large-scale system needed for the retrieval of proper nouns. There was increased activity in early visual cortices, suggesting intensification of visual processing to compensate for the defective preferred name retrieval processing.
Details
- Title: Subtitle
- Residual naming after damage to the left temporal pole: a PET activation study
- Creators
- Thomas J Grabowski - Department of Neurology, The University of Iowa College of Medicine, Iowa City, IA 52242, USAHanna Damasio - Department of Neurology, The University of Iowa College of Medicine, Iowa City, IA 52242, USADaniel Tranel - Department of Neurology, The University of Iowa College of Medicine, Iowa City, IA 52242, USAGregory E Cooper - Department of Neurology, University of Kentucky, Lexington, KY, USALaura L.Boles Ponto - Department of Radiology, The University of Iowa College of Medicine, Iowa City, IA 52242, USAG.Leonard Watkins - Department of Radiology, The University of Iowa College of Medicine, Iowa City, IA 52242, USARichard D Hichwa - Department of Radiology, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.19(3), pp.846-860
- DOI
- 10.1016/S1053-8119(03)00109-5
- PMID
- 12880813
- NLM abbreviation
- Neuroimage
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2003
- Academic Unit
- Neurology; Radiology; Research Administration; Psychological and Brain Sciences; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984002435202771
Metrics
27 Record Views