Journal article
Residual vascular dysfunction in women with a history of preeclampsia
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.315(6), pp.R1062-R1071
12/01/2018
DOI: 10.1152/ajpregu.00204.2018
PMCID: PMC6734059
PMID: 30133302
Abstract
Preeclampsia is a hypertensive disorder of pregnancy characterized by new-onset hypertension, proteinuria, and edema occurring after 20 wk of gestation, with a prevalence of similar to 7-10% of pregnancies in the United States and similar to 8 million pregnancies worldwide. Despite the postpartum remission of preeclamptic symptoms, women who have had preeclampsia are two to four times more likely to develop cardiovascular disease (CVD) and are significantly more likely to die of CVD compared with women with a history of normal pregnancy. Although the relation between history of preeclampsia and elevated CVD risk is well documented, the mechanism(s) underlying this association remains unclear. One hypothesis explaining this association is that the initial vascular damage and dysfunction sustained during the preeclamptic pregnancy persist chronically. Indeed, even in the absence of, or in advance of, overt CVD women who have had preeclampsia have compromised vascular endothelial function. Emerging mechanistic studies in these women have provided some insight into the underlying mechanisms of this persistent vascular dysfunction and have begun to identify potential therapeutic targets for the prevention or mitigation of CVD progression in this vulnerable population. This review summarizes the existing literature examining vascular function and dysfunction in women with a history of preeclampsia and highlights future directions for mechanistic investigations and development of novel intervention strategies aimed at halting or slowing the progression of CVD in these women.
Details
- Title: Subtitle
- Residual vascular dysfunction in women with a history of preeclampsia
- Creators
- Anna E. Stanhewicz - Pennsylvania State University
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.315(6), pp.R1062-R1071
- Publisher
- Amer Physiological Soc
- DOI
- 10.1152/ajpregu.00204.2018
- PMID
- 30133302
- PMCID
- PMC6734059
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Number of pages
- 10
- Grant note
- K99HL138133 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) HL-138133 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 12/01/2018
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984259652802771
Metrics
4 Record Views