Journal article
Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns
AIDS (London), Vol.19(18), pp.2167-2169
2005
DOI: 10.1097/01.aids.0000194800.43799.94
PMID: 16284468
Abstract
The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants who were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).
Details
- Title: Subtitle
- Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns
- Creators
- Susan H ESHLEMAN - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, United StatesDonald R HOOVER - Department of Statistics and Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, NJ, United StatesNewton KUMWENDA - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesTaha TAHA - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesShu Chen - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesSarah E HUDELSON - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, United StatesLaura A GUAY - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, United StatesAnthony MWATHA - Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United StatesSusan A FISCUS - Department of Microbiol ogy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesFrancis MMIRO - Department of Obstetrics and Gynaecology, Makerere University, Kampala, UgandaPhilippa MUSOKE - Department of Paediatrics, Makerere University, Kampala, UgandaJ. Brooks JACKSON - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- AIDS (London), Vol.19(18), pp.2167-2169
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1097/01.aids.0000194800.43799.94
- PMID
- 16284468
- ISSN
- 0269-9370
- eISSN
- 1473-5571
- Language
- English
- Date published
- 2005
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047683102771
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