Journal article
Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy
Journal of applied physiology (1985), Vol.116(6), pp.693-702
03/01/2014
DOI: 10.1152/japplphysiol.01366.2013
PMID: 24458751
Abstract
We sought to determine whether acute resistance exercise (RE)-induced gene expression is modified by RE training. We studied the expression patterns of a select group of genes following an acute bout of RE in naive and hypertrophying muscle. Thirteen untrained subjects underwent supervised RE training for 12 wk of the nondominant arm and performed an acute bout of RE 1 wk after the last bout of the training program (training + acute). The dominant arm was either unexercised (control) or subjected to the same acute exercise bout as the trained arm (acute RE). Following training, men (14.8 +/- 2.8%; P < 0.05) and women (12.6 +/- 2.4%; P < 0.05) underwent muscle hypertrophy with increases in dynamic strength in the trained arm (48.2 +/- 5.4% and 72.1 +/- 9.1%, respectively; P < 0.01). RE training resulted in attenuated anabolic signaling as reflected by a reduction in rpS6 phosphorylation following acute RE. Changes in mRNA levels of genes involved in hypertrophic growth, protein degradation, angiogenesis, and metabolism commonly expressed in both men and women was determined 4 h following acute RE. We show that RE training can modify acute RE-induced gene expression in a divergent and gene-specific manner even in genes belonging to the same ontology. Changes in gene expression following acute RE are multidimensional, and may not necessarily reflect the actual adaptive response taking place during the training process. Thus RE training can selectively modify the acute response to RE, thereby challenging the use of gene expression as a marker of exercise-induced adaptations.
Details
- Title: Subtitle
- Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy
- Creators
- G. A. Nader - Karolinska InstituteF. von Walden - Karolinska InstituteC. Liu - Karolinska InstitutetJ. Lindvall - Karolinska InstituteL. Gutmann - University of IowaE. E. Pistilli - West Virginia UniversityP. M. Gordon - Baylor University
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.116(6), pp.693-702
- Publisher
- Amer Physiological Soc
- DOI
- 10.1152/japplphysiol.01366.2013
- PMID
- 24458751
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Number of pages
- 10
- Grant note
- Centrum for Idrottsforskning Diabetesforbundet Kung Gustaf V:s 80 Arsfond Swedish Research Council; European Commission
- Language
- English
- Date published
- 03/01/2014
- Academic Unit
- Neurology
- Record Identifier
- 9984303435302771
Metrics
1 Record Views