Respiratory Syncytial Virus Provides Protection against a Subsequent Influenza A Virus Infection

Stacey M Hartwig; Ann M Miller; Steven M Varga

doi:10.4049/jimmunol.2000751

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Respiratory Syncytial Virus Provides Protection against a Subsequent Influenza A Virus Infection

Journal article

Peer reviewed

Respiratory Syncytial Virus Provides Protection against a Subsequent Influenza A Virus Infection

Stacey M Hartwig, Ann M Miller and Steven M Varga

The Journal of immunology (1950), Vol.208(3), pp.720-731

02/01/2022

DOI: 10.4049/jimmunol.2000751

PMCID: PMC8851717

PMID: 35022269

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Abstract

Respiratory infections are a leading cause of morbidity and mortality. The presence of multiple heterologous virus infections is routinely observed in a subset of individuals screened for the presence of respiratory viruses. However, the impact overlapping infections has on disease severity and the host immune response is not well understood. Respiratory syncytial virus (RSV) and influenza A virus (IAV) are two of the most common respiratory infections observed in hospitalized patients, particularly in the very young and aged populations. In this study, we examined how the order in which BALB/c mice were infected with both RSV and IAV impacts disease severity. RSV infection prior to an IAV infection was associated with decreased weight loss and increased survival as compared with IAV infection alone. In contrast, IAV infection prior to an RSV infection was associated with similar morbidity and mortality as compared with an IAV infection alone. Our results suggest that the order in which viral infections are acquired plays a critical role in the outcome of disease severity and the host immune response.

Animals

Antibodies, Viral - immunology

CD8-Positive T-Lymphocytes - immunology

Coinfection - immunology

Coinfection - virology

Cytokines - immunology

Female

Influenza A virus - immunology

Interferon Type I - immunology

Mice

Mice, Inbred BALB C

Orthomyxoviridae Infections - immunology

Orthomyxoviridae Infections - prevention & control

Respiratory Syncytial Virus Infections - immunology

Respiratory Syncytial Viruses - immunology

Viral Interference - physiology

Details

Title: Subtitle: Respiratory Syncytial Virus Provides Protection against a Subsequent Influenza A Virus Infection
Creators: Stacey M Hartwig - University of Iowa
Ann M Miller - University of Iowa
Steven M Varga - University of Iowa
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.208(3), pp.720-731
DOI: 10.4049/jimmunol.2000751
PMID: 35022269
PMCID: PMC8851717
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Grant note: R01 AI124093 / NIAID NIH HHS
Language: English
Date published: 02/01/2022
Academic Unit: Graduate College Admin and Gen; Microbiology and Immunology; Pathology
Record Identifier: 9984297317602771

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