Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice

Ahmed R Alsuwaidi; Alia Albawardi; Saeeda Almarzooqi; Sheela Benedict; Aws R Othman; Stacey M Hartwig; Steven M Varga; Abdul-Kader Souid

doi:10.1016/j.virol.2014.02.028

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Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice

Journal article

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Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice

Ahmed R Alsuwaidi, Alia Albawardi, Saeeda Almarzooqi, Sheela Benedict, Aws R Othman, Stacey M Hartwig, Steven M Varga and Abdul-Kader Souid

Virology (New York, N.Y.), Vol.454-455(1), pp.263-269

04/2014

DOI: 10.1016/j.virol.2014.02.028

PMID: 24725953

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Abstract

We have previously reported that lung cellular bioenergetics (cellular respiration and ATP) increased in 4–10 week-old BALB/c mice infected with respiratory syncytial virus (RSV). This study examined the kinetics and changes in cellular bioenergetics in ≤2-week-old C57BL/6 mice following RSV infection. Mice (5–14 days old) were inoculated intranasally with RSV and the lungs were examined on days 1–10 post-infection. Histopathology and electron microscopy revealed preserved pneumocyte architectures and organelles. Increased lung cellular bioenergetics was noted from days 1–10 post-infection. Cellular GSH remained unchanged. These results indicate that the increased lung cellular respiration (measured by mitochondrial O2 consumption) and ATP following RSV infection is independent of either age or genetic background of the host. [Display omitted] •RSV infection increases lung cellular respiration and ATP in neonatal C57BL/6 mice.•Increased lung cellular bioenergetics is a biomarker of RSV infection.•Lung cellular glutathione remains unchanged in RSV infection.

Neonates

Mitochondria

Respiratory syncytial virus

Cellular respiration

Oxygen consumption

Mice

Cellular ATP

C57BL/6

Details

Title: Subtitle: Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice
Creators: Ahmed R Alsuwaidi - Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates
Alia Albawardi - Departments of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates
Saeeda Almarzooqi - Departments of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates
Sheela Benedict - Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates
Aws R Othman - Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates
Stacey M Hartwig - Department of Microbiology, Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
Steven M Varga - Department of Microbiology, Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
Abdul-Kader Souid - Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates
Resource Type: Journal article
Publication Details: Virology (New York, N.Y.), Vol.454-455(1), pp.263-269
DOI: 10.1016/j.virol.2014.02.028
PMID: 24725953
NLM abbreviation: Virology
ISSN: 0042-6822
eISSN: 1096-0341
Publisher: Elsevier Inc
Language: English
Date published: 04/2014
Academic Unit: Graduate College Admin and Gen; Microbiology and Immunology; Pathology
Record Identifier: 9984083879502771

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