Response categorization and outcomes in extremely premature infants born at 22-26 weeks gestation that received inhaled nitric oxide for hypoxic respiratory failure

Timothy J Boly; John M Dagle; Jonathan M Klein; Danielle R Rios; Patrick J McNamara; Regan E Giesinger

doi:10.1038/s41372-022-01582-4

Back

Response categorization and outcomes in extremely premature infants born at 22-26 weeks gestation that received inhaled nitric oxide for hypoxic respiratory failure

Journal article

Open access

Peer reviewed

Response categorization and outcomes in extremely premature infants born at 22-26 weeks gestation that received inhaled nitric oxide for hypoxic respiratory failure

Timothy J Boly, John M Dagle, Jonathan M Klein, Danielle R Rios, Patrick J McNamara and Regan E Giesinger

Journal of perinatology, Vol.43(3), pp.324-331

2023

DOI: 10.1038/s41372-022-01582-4

PMCID: PMC10173872

PMID: 36509816

Files and links (1)

url

https://pmc.ncbi.nlm.nih.gov/articles/PMC10173872/pdf/nihms-1893978.pdfView

Open Access

Abstract

To evaluate the outcomes of extremely premature infants who received inhaled nitric oxide(iNO) for hypoxic respiratory failure(HRF). Retrospective analysis of 107 infants born 22-26 weeks gestation who received iNO for HRF at a single institution. Infants were categorized as positive, negative, or no responders based on change in FiO or OI. Underlying physiology was determined using Echocardiography/Radiography/Biochemistry. 63% of infants had a positive response; they received iNO earlier and were more likely to have acute pulmonary hypertension(PH). Positive response correlated with decreased incidence of death or grade 3 BPD at 36 weeks postmenstrual age, as compared to a negative response. Extremely premature infants have a positive response rate to iNO comparable to term infants when used for PH in the transitional period. Infants with a negative response to iNO had worse outcomes, necessitating the determination of the underlying physiology of HRF prior to iNO initiation.

Details

Title: Subtitle: Response categorization and outcomes in extremely premature infants born at 22-26 weeks gestation that received inhaled nitric oxide for hypoxic respiratory failure
Creators: Timothy J Boly - University of Iowa
John M Dagle - University of Iowa
Jonathan M Klein - Department of Pediatrics, University of Iowa, Iowa City, IA, USA
Danielle R Rios - University of Iowa
Patrick J McNamara - Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
Regan E Giesinger - Department of Pediatrics, University of Iowa, Iowa City, IA, USA. regan-giesinger@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.43(3), pp.324-331
DOI: 10.1038/s41372-022-01582-4
PMID: 36509816
PMCID: PMC10173872
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Language: English
Electronic publication date: 12/12/2022
Date published: 2023
Academic Unit: Stead Family Department of Pediatrics; Epidemiology; Biochemistry and Molecular Biology; Neonatology; Internal Medicine
Record Identifier: 9984327060302771

Metrics

31 Record Views

12 Times Cited - Web of Science

See more details