Journal article
Response of Muscular and Cutaneous Vessels to Physiologic Stimulation of Chemoreceptors
Proceedings of the Society for Experimental Biology and Medicine, Vol.148(1), pp.198-202
01/1975
DOI: 10.3181/00379727-148-38505
PMID: 236568
Abstract
Summary
Experiments were performed to determine whether physiologic stimulation of carotid chemoreceptors produces different responses in blood vessels of skin and muscle. Carotid chemoreceptors of anesthetized dogs were stimulated with hypoxic and hypercapnic blood and responses were observed in the isolated, perfused gracilis muscle and hindpaw. Chemoreceptor stimulation produced vasoconstriction in the muscle and vasodilatation in the paw (a predominantly cutaneous vascular bed). Responses to hy-poxia without hypercapnic acidosis tended to be less pronounced. The study indicates that physiologic stimulation of carotid chemoreceptors produces contrasting responses in different vascular beds.
This study was supported by Clinical Investigator-ships from the Veterans Administration, by research Grants Nos. HL 09835, HL 02644, HL 14388, and HL 16066, and Research Career Development Award HL-K4-28749 from the National Heart and Lung Institute, and by grants from the American and Iowa Heart Associations.
Details
- Title: Subtitle
- Response of Muscular and Cutaneous Vessels to Physiologic Stimulation of Chemoreceptors
- Creators
- Donald D HeistadFrancois M AbboudAllyn L MarkPhillip G Schmid
- Resource Type
- Journal article
- Publication Details
- Proceedings of the Society for Experimental Biology and Medicine, Vol.148(1), pp.198-202
- Publisher
- SAGE Publications; London, England
- DOI
- 10.3181/00379727-148-38505
- PMID
- 236568
- ISSN
- 0037-9727
- eISSN
- 1535-3699
- Language
- English
- Date published
- 01/1975
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025584202771
Metrics
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