Journal article
Response of Spinal Cord Blood Flow to the Nitric Oxide Inhibitor Nitroarginine
Neurosurgery, Vol.39(4), pp.795-802
10/01/1996
DOI: 10.1097/00006123-199610000-00030
PMID: 8880775
Abstract
OBjECTIVE:
The extent to which nitric oxide (NO) is involved in the modulation of spinal cord blood flow (SCBF) in the uninjured and injured cord is unknown. To elucidate these questions, the following experiments in anesthetized rats were conducted.
METHODS:
Because NO is an unstable free radical with a half-life of seconds, its role can be understood through the study of the NO synthase inhibitor L-ZS^-nitroarginine (L-NOARG). L-NOARG was administered intravenously for 30 minutes at a dose of 100 or 500 fig/kg/min in 12 and 10 uninjured animals, respectively. SCBF fluctuations at C7-T1 were measured using laser doppler flowmetry. In a second set of 12 rats, L-NOARG (500/Mg/kg/min) was administered 10 minutes before spinal cord injury using a modified aneurysm clip at C7-T1 and continued for 30 minutes thereafter.
RESULTS:
In the uninjured animals, L-NOARG was associated with a dose-dependent increase in mean arterial pressure of 20 to 80% above baseline (P = 0.0001), together with a dose-related decrease in SCBF (P = 0.0373). In the injured animals, L-NOARG was associated with a 48% increase in mean arterial pressure. With L-NOARG, the changes in SCBF from baseline after injury were similar to those of noninjured controls (n = 25) and significantly less than injury controls (n = 18) or those receiving phenylephrine (n = 8).
CONCLUSION:
NO synthase inhibitors, by reducing available NO, cause systemic vasoconstriction and a decrease in SCBF in the uninjured spinal cord. In the injured spinal cord, the administration of L-NOARG results in a redistribution of blood flow with an augmentation in posttraumatic SCBF at the injury site.
Details
- Title: Subtitle
- Response of Spinal Cord Blood Flow to the Nitric Oxide Inhibitor Nitroarginine
- Creators
- Patrick W Hitchon - Department of Surgery, Division of Neurosurgery, College of Medicine, The University of Iowa, Veterans Administration Medical Center, Iowa City, IowaLoren J Mouw - Department of Surgery, Division of Neurosurgery, College of Medicine, The University of Iowa, Veterans Administration Medical Center, Iowa City, IowaThomas N Rogge - Department of Surgery, Division of Neurosurgery, College of Medicine, The University of Iowa, Veterans Administration Medical Center, Iowa City, IowaJames C Torner - Department of Preventive Medicine and Environmental Health, Division of Epidemiology, College of Medicine, The University of Iowa, Veterans Administration Medical Center, Iowa City, IowaAdrienne K Miller - Department of Surgery, Division of Neurosurgery, College of Medicine, The University of Iowa, Veterans Administration Medical Center, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Neurosurgery, Vol.39(4), pp.795-802
- DOI
- 10.1097/00006123-199610000-00030
- PMID
- 8880775
- NLM abbreviation
- Neurosurgery
- ISSN
- 0148-396X
- eISSN
- 1524-4040
- Language
- English
- Date published
- 10/01/1996
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984040011002771
Metrics
13 Record Views