Response of native and stimulated collateral vessels to serotonin

Kathryn G Lamping

doi:10.1152/ajpheart.1997.272.5.H2409

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Response of native and stimulated collateral vessels to serotonin

Journal article

Peer reviewed

Response of native and stimulated collateral vessels to serotonin

Kathryn G Lamping

The American journal of physiology, Vol.272(5 Pt 2), pp.H2409-H2415

05/1997

DOI: 10.1152/ajpheart.1997.272.5.H2409

PMID: 9176312

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Abstract

Previous studies suggest that collateral vessels constrict in response to serotonin. The objective of these studies was to directly measure responses of native and stimulated collateral vessels 30-400 microns in diameter to serotonin and to determine the mechanisms involved in responses to serotonin. Serotonin was suffused onto the left ventricle of dogs, and microvascular diameters were measured with computer-controlled stroboscopic illumination coupled to a microscope-video system. Stimulated collateral vessels and arterioles in collateral-dependent myocardium were measured after Ameroid constriction of the left circumflex artery. Noncollateral and native collateral vessels were examined in dogs without a constrictor. Serotonin produced dose-dependent dilation of noncollateral vessels that was decreased in native collateral vessels, stimulated collateral vessels, and vessels in collateral-dependent myocardium. Dilation in response to nitroprusside was similar in all groups. Dilation in response to serotonin was enhanced by inhibition of 5-hydroxytryptamine (5-HT)2 receptors with ketanserin and blocked by nonselective 5-HT1 and 5-HT2 receptors with methiothepin. Inhibition of nitric oxide (NO) synthase with NG-nitro-L-arginine decreased dilation in response to serotonin. Thus collaterals and arterioles in collateral-dependent myocardium are less sensitive to the dilating effect of serotonin. Responses to serotonin involve a balance between dilation mediated by 5-HT1 receptors and constriction mediated by 5-HT2 receptors.

Arterioles - physiology

Ketanserin - pharmacology

Arterioles - anatomy & histology

Methiothepin - pharmacology

Male

Nitric Oxide - physiology

Serotonin - pharmacology

Arterioles - drug effects

Microcirculation - drug effects

Nitroarginine - pharmacology

Animals

Dogs

Female

Blood Pressure - drug effects

Coronary Circulation - drug effects

Coronary Vessels - anatomy & histology

Details

Title: Subtitle: Response of native and stimulated collateral vessels to serotonin
Creators: Kathryn G Lamping - Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.272(5 Pt 2), pp.H2409-H2415
DOI: 10.1152/ajpheart.1997.272.5.H2409
PMID: 9176312
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Grant note: HL-39050 / NHLBI NIH HHS
Language: English
Date published: 05/1997
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984094727102771

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