Journal article
Response to cyclosporine A in a patient with pure red cell aplasia due to antierythropoietin-alpha antibodies
Seminars in dialysis, Vol.19(3), pp.251-255
05/2006
DOI: 10.1111/j.1525-139X.2006.00163.x
PMID: 16689978
Abstract
Reported cases of pure red cell aplasia (PRCA) from the administration of erythropoietin (EPO)-alpha molecule in the United States are rare, and the optimal treatment is still unknown. We present a patient with end-stage renal disease (ESRD) who became hyporesponsive and later unresponsive to EPO-alpha treatment a few months after initiation of hemodialysis. A comprehensive anemia examination was negative while the patient became transfusion dependent. The diagnosis of EPO-alpha-induced PRCA was confirmed by bone marrow biopsy, by undetectable serum EPO levels following the administration of a large dose of EPO-alpha, and by documenting the presence of EPO-neutralizing antibodies. Administration of cyclosporine A in addition to prednisone enabled the patient to become transfusion and EPO independent. This case further documents the possible occurrence of PRCA with EPO-alpha administration in the United States and reaffirms the potential beneficial effect of cyclosporine A.
Details
- Title: Subtitle
- Response to cyclosporine A in a patient with pure red cell aplasia due to antierythropoietin-alpha antibodies
- Creators
- Mony Fraer - Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, USAAdam CampbellB Peter Sawaya
- Resource Type
- Journal article
- Publication Details
- Seminars in dialysis, Vol.19(3), pp.251-255
- DOI
- 10.1111/j.1525-139X.2006.00163.x
- PMID
- 16689978
- ISSN
- 0894-0959
- eISSN
- 1525-139X
- Language
- English
- Date published
- 05/2006
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094339102771
Metrics
7 Record Views