Journal article
Responses of CD8 + T cells to intracellular bacteria
Current opinion in immunology, Vol.11(1), pp.89-93
1999
DOI: 10.1016/S0952-7915(99)80016-8
PMID: 10047532
Abstract
Recent studies of CD8
+ T cell responses against intracellular bacteria have provided insights into the relevance of the exogenous and endogenous MHC class I presentation pathways during the priming and effector stages. The capacity of these organisms to deliver vaccine antigens, either as bacterial protein or as plasmid DNA expressed by host antigen-presenting cells, has been investigated. Ongoing studies of CD8
+ T cell effector functions suggest the existence of novel pathways of resistance to bacterial infection. These results, together with advances in our understanding of nonclassical MHC class I presentation, reveal the impact of pathogen biology on host immunity to infection.
Details
- Title: Subtitle
- Responses of CD8 + T cells to intracellular bacteria
- Creators
- John T Harty - Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USAMichael J Bevan - Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in immunology, Vol.11(1), pp.89-93
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0952-7915(99)80016-8
- PMID
- 10047532
- ISSN
- 0952-7915
- eISSN
- 1879-0372
- Language
- English
- Date published
- 1999
- Academic Unit
- Pathology
- Record Identifier
- 9984046809802771
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