Journal article
Responses of cerebral arterioles to N-methyl- d-aspartate and activation of ATP-sensitive potassium channels in old rats
Brain research, Vol.654(2), pp.349-351
1994
DOI: 10.1016/0006-8993(94)90499-5
PMID: 7987685
Abstract
The first goal of this study was to examine the hypothesis that aging impairs dilator responses of cerebral arterioles to
N-methyl-
d-aspartate (NMDA). The second goal was to determine whether aging impairs vasodilatation in response to activation of ATP-sensitive K
+ channels. Diameter of cerebral arterioles was measured through a cranial window in anesthetized adult (5 ± 1 (mean ±S.E.)months old) and old (26 ± 1months old) Fischer 344 rats. In adult rats NMDA (10 and 100 μM) dilated pial arterioles by 14 ± 5 and 72 ± 9%, respectively, from a control diameter of 36 ± 5 μm. Aprikalim (1 and 10 μM), a direct activator of ATP-sensitive potassium channels, dilated cerebral arterioles in adult rats by 14 ± 3 and 49 ± 6%, respectively. Vasodilatation in response to NMDA and aprikalim were similar in old and adult rats. Thus, in contrast to impaired cerebral vasodilator responses to some stimuli, responses of cerebral arterioles to NMDA and activation of ATP-sensitive potassium channels are preserved in old Fischer 344 rats.
Details
- Title: Subtitle
- Responses of cerebral arterioles to N-methyl- d-aspartate and activation of ATP-sensitive potassium channels in old rats
- Creators
- Frank M FaraciDonald D Heistad
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.654(2), pp.349-351
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(94)90499-5
- PMID
- 7987685
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1994
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040217502771
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