Journal article
Responses of endothelial cells, smooth muscle cells, and platelets dependent on the surface topography of polytetrafluoroethylene
Journal of biomedical materials research. Part A, Vol.104(9), pp.2291-2304
09/2016
DOI: 10.1002/jbm.a.35763
PMID: 27119260
Abstract
In this study, the effect of different structures (flat, expanded, and electrospun) of polytetrafluoroethylene (PTFE) on the interactions of endothelial cells (ECs), smooth muscle cells (SMCs), and platelets was investigated. In addition, the mechanisms that govern the interactions between ECs, SMCs, and platelets with different structures of PTFE were discussed. The surface characterizations showed that the different structures of PTFE have the same surface chemistry, similar surface wettability and zeta potential, but uniquely different surface topography. The viability, proliferation, morphology, and phenotype of ECs and SMCs interacted with different structures of PTFE were investigated. Expanded PTFE (ePTFE) provided a relatively better surface for the growth of ECs. In case of SMC interactions, although all the different structures of PTFE inhibited SMC growth, a maximum inhibitory effect was observed for ePTFE. In case of platelet interactions, the electrospun PTFE provided a better surface for preventing the adhesion and activation of platelets. Thus, this study demonstrated that the responses of ECs, SMCs, and platelets strongly dependent on the surface topography of the PTFE. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2291-2304, 2016.
Details
- Title: Subtitle
- Responses of endothelial cells, smooth muscle cells, and platelets dependent on the surface topography of polytetrafluoroethylene
- Creators
- Sujan Lamichhane - University of South DakotaJordan A Anderson - University of South DakotaTyler Remund - Sanford ResearchHongli Sun - University of South DakotaMark K Larson - Department of Biology, Augustana University, 2001 S. Summit Avenue, Sioux Falls, South Dakota, 57197Patrick Kelly - Sanford HealthGopinath Mani - University of South Dakota
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part A, Vol.104(9), pp.2291-2304
- DOI
- 10.1002/jbm.a.35763
- PMID
- 27119260
- NLM abbreviation
- J Biomed Mater Res
- ISSN
- 0021-9304
- eISSN
- 1552-4965
- Language
- English
- Date published
- 09/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery
- Record Identifier
- 9984367725402771
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