Responsiveness of longitudinal and circular muscle layers of the portal vein

Bruce P Brown; Sinn Anuras; Donald D Heistad

doi:10.1152/ajpgi.1982.242.5.G498

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Responsiveness of longitudinal and circular muscle layers of the portal vein

Journal article

Peer reviewed

Responsiveness of longitudinal and circular muscle layers of the portal vein

Bruce P Brown, Sinn Anuras and Donald D Heistad

The American journal of physiology, Vol.242(5), pp.G498-G503

05/1982

DOI: 10.1152/ajpgi.1982.242.5.G498

PMID: 7081443

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Abstract

This study was performed to compare mechanical activity produced by acetylcholine and histamine in longitudinal and circular muscle layers of the portal vein. Peak tension was measured in longitudinal and circular muscle strips from portal veins of rabbits as they were superfused with acetylcholine and histamine (10(-6) to 10(-4) M). Responses to acetylcholine were three to four times greater in longitudinal muscle than in circular muscle; for example, acetylcholine (10(-5) M) produced contractions of 1.6 +/- 0.2 X 10(3) (mean +/- SE) dynes in longitudinal muscle and 0.4 +/- 0.09 X 10(3) dynes in circular muscle. In the same strips, histamine produced similar responses in the two layers: histamine (10(-5) M) produced contractions of 0.4 +/- 0.1 X 10(3) dynes in longitudinal and 0.4 +/- 0.1 X 10(3) dynes in circular muscle. Histological studies of portal vein muscle strips showed that the longitudinal muscle layer is three to four times thicker than the circular muscle layer. Thus, in response to acetylcholine, tension developed in each muscle layer is proportional to the thickness of that layer. In response to histamine, however, longitudinal muscle develops less tension than is predicted by the thickness of the muscle layer. We conclude that longitudinal and circular muscle layers of the rabbit portal vein differ in their responsiveness to histamine.

Portal Vein - physiology

Rabbits

Animals

Histamine - pharmacology

Portal Vein - anatomy & histology

Acetylcholine - pharmacology

Cimetidine - pharmacology

Muscle, Smooth, Vascular - anatomy & histology

Chlorpheniramine - pharmacology

Muscle, Smooth, Vascular - physiology

Muscle, Smooth, Vascular - drug effects

Details

Title: Subtitle: Responsiveness of longitudinal and circular muscle layers of the portal vein
Creators: Bruce P Brown
Sinn Anuras
Donald D Heistad
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.242(5), pp.G498-G503
DOI: 10.1152/ajpgi.1982.242.5.G498
PMID: 7081443
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Publisher: American Physiological Society; United States
Grant note: HL00795-01 / NHLBI NIH HHS
Language: English
Date published: 05/1982
Academic Unit: Radiology; Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040438102771

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