Journal article
Resting EEG in offspring of male alcoholics: beta frequencies
International journal of psychophysiology, Vol.51(3), pp.239-251
2004
DOI: 10.1016/j.ijpsycho.2003.09.003
PMID: 14962576
Abstract
This study examines the differences in beta (12–28 Hz) band power in offspring of male alcoholics from densely affected alcoholic families. We have attempted to investigate if the increase in beta power is a ‘state’ or ‘trait’ marker for alcoholism. This study also explores the gender differences in the expression of this potential risk marker. Absolute beta power in three bands—beta 1(12–16 Hz), beta 2 (16–20 Hz), and beta 3 (20–28 Hz)—in the eyes closed EEG of 171 high risk (HR) subjects who were offspring of male alcoholics and 204 low risk (LR) subjects with no family history of alcoholism, were compared for each gender separately using a repeated measures analysis of variance design. Alcoholic and non-alcoholic subjects within the high risk group were compared using a repeated measures design as a follow-up analysis. The present study demonstrated increased beta power in the resting EEG of offspring of male alcoholics. Male HR subjects had higher beta 1 (12–16 Hz) power and female HR subjects had increased power in beta 2 (16–20 Hz) and beta 3 (20–28 Hz) as compared with low risk participants. Female HR subjects also showed significantly increased beta 2 and beta 3 power if they had two or more alcoholic first-degree relatives when compared with HR females having only an affected father. Risk characteristics are expressed differentially in males and females and may be an index of differential vulnerability to alcoholism. The results indicate that increased EEG beta power can be considered as a likely marker of risk for developing alcoholism and may be used as a predictive endophenotype.
Details
- Title: Subtitle
- Resting EEG in offspring of male alcoholics: beta frequencies
- Creators
- Madhavi Rangaswamy - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USABernice Porjesz - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USADavid B Chorlian - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USAKongming Wang - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USAKevin A Jones - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USASamuel Kuperman - University of Iowa Hospitals, Division of Child Psychiatry, Iowa City, IA 52242, USAJohn Rohrbaugh - Washington University-Division of Family Studies, St. Louis, MO 63108, USASean J O'Connor - Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, Indianapolis, IN 46202, USALance O Bauer - Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USATheodore Reich - Department of Psychiatry, Washington University, School of Medicine, St. Louis, MO 63110, USAHenri Begleiter - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA
- Resource Type
- Journal article
- Publication Details
- International journal of psychophysiology, Vol.51(3), pp.239-251
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ijpsycho.2003.09.003
- PMID
- 14962576
- ISSN
- 0167-8760
- eISSN
- 1872-7697
- Language
- English
- Date published
- 2004
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003448502771
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