Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study

Judith Hsia; Joseph C Larson; Judith K Ockene; Gloria E Sarto; Matthew A Allison; Susan L Hendrix; Jennifer G Robinson; Andrea Z LaCroix; JoAnn E Manson; Women's Health Initiative Research Group

doi:10.1136/bmj.b219

Back

Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study

Journal article

Open access

Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study

Judith Hsia, Joseph C Larson, Judith K Ockene, Gloria E Sarto, Matthew A Allison, Susan L Hendrix, Jennifer G Robinson, Andrea Z LaCroix, JoAnn E Manson and Women's Health Initiative Research Group

BMJ (Clinical research ed.), Vol.338(7694), pp.b219-579

02/03/2009

DOI: 10.1136/bmj.b219

PMCID: PMC2640113

PMID: 19193613

Files and links (1)

url

https://doi.org/10.1136/bmj.b219View

Published (Version of record) Open Access

Abstract

To evaluate resting heart rate as an independent predictor of cardiovascular risk in women. Prospective cohort study. The Women's Health Initiative was undertaken at 40 research clinics in the United States. 129 135 postmenopausal women. Clinical cardiovascular events. During a mean of 7.8 (SD 1.6) years of follow up, 2281 women were identified with myocardial infarction or coronary death and 1877 with stroke. We evaluated associations between resting heart rate and cardiovascular events in Cox regression models adjusted for multiple covariates. Higher resting heart rate was independently associated with coronary events (hazard ratio 1.26, 95% confidence interval 1.11 to 1.42 for highest [>76 beats per minute] v lowest quintile [<or=62 beats per minute]; P=0.001), but not with stroke. The relation between heart rate and coronary events did not differ between white women and women from other ethnic groups (P for interaction=0.45) or between women with and without diabetes (P for interaction=0.31), but it was stronger in women aged 50-64 at baseline than in those aged 65-79 (P for interaction=0.009). Resting heart rate, a low tech and inexpensive measure of autonomic tone, independently predicts myocardial infarction or coronary death, but not stroke, in women. ClinicalTrials.gov NCT00000611.

Myocardial Infarction - diagnosis

Prognosis

Humans

Middle Aged

Stroke - diagnosis

Death, Sudden, Cardiac - prevention & control

Stroke - physiopathology

Rest - physiology

Epidemiologic Methods

Heart Rate - physiology

Female

Myocardial Infarction - physiopathology

Aged

Postmenopause - physiology

Details

Title: Subtitle: Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study
Creators: Judith Hsia - George Washington University, Washington, DC 20037, USA. judith.hsia@astrazeneca.com
Joseph C Larson
Judith K Ockene
Gloria E Sarto
Matthew A Allison
Susan L Hendrix
Jennifer G Robinson
Andrea Z LaCroix
JoAnn E Manson
Women's Health Initiative Research Group
Resource Type: Journal article
Publication Details: BMJ (Clinical research ed.), Vol.338(7694), pp.b219-579
DOI: 10.1136/bmj.b219
PMID: 19193613
PMCID: PMC2640113
NLM abbreviation: BMJ
ISSN: 1756-1833
eISSN: 1756-1833
Publisher: England
Grant note: N01WH42123 / WHI NIH HHS N01WH32111 / WHI NIH HHS N01WH42132 / WHI NIH HHS N01WH42118 / WHI NIH HHS N01WH42114 / WHI NIH HHS N01WH42110 / WHI NIH HHS N01WH32106 / WHI NIH HHS N01WH32119 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32102 / WHI NIH HHS N01WH24152 / WHI NIH HHS N01WH32101 / WHI NIH HHS N01WH42131 / WHI NIH HHS N01WH42108 / WHI NIH HHS N01WH42126 / WHI NIH HHS N01WH42113 / WHI NIH HHS N01WH42117 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH32109 / WHI NIH HHS N01WH32105 / WHI NIH HHS N01WH32118 / WHI NIH HHS N01WH42122 / WHI NIH HHS N01WH42107 / WHI NIH HHS N01WH42130 / WHI NIH HHS N01WH42125 / WHI NIH HHS N01WH42112 / WHI NIH HHS N01WH42129 / WHI NIH HHS N01WH32122 / WHI NIH HHS N01WH42116 / WHI NIH HHS N01WH32108 / WHI NIH HHS N01WH32113 / WHI NIH HHS N01WH32100 / WHI NIH HHS N01WH42121 / WHI NIH HHS N01WH42115 / WHI NIH HHS N01WH42124 / WHI NIH HHS N01WH32112 / WHI NIH HHS N01WH42119 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH42111 / WHI NIH HHS N01WH42120 / WHI NIH HHS N01WH42109 / WHI NIH HHS
Language: English
Date published: 02/03/2009
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983996081602771

Metrics

15 Record Views

96 Times Cited - Web of Science