Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms

J Ferri; J. M Ford; B. J Roach; J. A Turner; T. G van Erp; J Voyvodic; A Preda; A Belger; J Bustillo; D O'Leary; B. A Mueller; K. O Lim; S. C McEwen; V. D Calhoun; M Diaz; G Glover; D Greve; C. G Wible; J. G Vaidya; S. G Potkin; D. H Mathalon

doi:10.1017/S003329171800003X

Back

Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms

Journal article

Peer reviewed

Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms

J Ferri, J. M Ford, B. J Roach, J. A Turner, T. G van Erp, J Voyvodic, A Preda, A Belger, J Bustillo, D O'Leary, …

Psychological medicine, Vol.48(15), pp.2492-2499

11/2018

DOI: 10.1017/S003329171800003X

PMCID: PMC12094034

PMID: 29444726

View Online

Abstract

Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cerebellum and prefrontal cortex as well as thalamic hyperconnectivity with sensory cortical regions in SZ patients compared with healthy comparison participants (HCs). However, fundamental questions remain regarding the clinical significance of these connectivity abnormalities.Method Resting state seed-based functional connectivity was used to investigate thalamus to whole brain connectivity using multi-site data including 183 SZ patients and 178 matched HCs. Statistical significance was based on a voxel-level FWE-corrected height threshold of p < 0.001. The relationships between positive and negative symptoms of SZ and regions of the brain demonstrating group differences in thalamic connectivity were examined.Results HC and SZ participants both demonstrated widespread positive connectivity between the thalamus and cortical regions. Compared with HCs, SZ patients had reduced thalamic connectivity with bilateral cerebellum and anterior cingulate cortex. In contrast, SZ patients had greater thalamic connectivity with multiple sensory-motor regions, including bilateral pre-and post-central gyrus, middle/inferior occipital gyrus, and middle/superior temporal gyrus. Thalamus to middle temporal gyrus connectivity was positively correlated with hallucinations and delusions, while thalamus to cerebellar connectivity was negatively correlated with delusions and bizarre behavior.Conclusions Thalamic hyperconnectivity with sensory regions and hypoconnectivity with cerebellar regions in combination with their relationship to clinical features of SZ suggest that thalamic dysconnectivity may be a core neurobiological feature of SZ that underpins positive symptoms

Original Articles

Details

Title: Subtitle: Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms
Creators: J Ferri - 1Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA
J. M Ford - 1Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA
B. J Roach - 2San Francisco VA Health Care System, San Francisco, CA, USA
J. A Turner - 3The Mind Research Network, Albuquerque, NM, USA
T. G van Erp - 4Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA
J Voyvodic - 5Department of Psychiatry, Duke University, Raleigh-Durham, NC, USA
A Preda - 4Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA
A Belger - 6Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
J Bustillo - 7Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA
D O'Leary - 8Department of Psychiatry, University of Iowa, Iowa City, IA, USA
B. A Mueller - 9Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
K. O Lim - 9Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
S. C McEwen - 10Department of Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA
V. D Calhoun - 3The Mind Research Network, Albuquerque, NM, USA
M Diaz - 5Department of Psychiatry, Duke University, Raleigh-Durham, NC, USA
G Glover - 12Department of Radiology, Stanford University, Stanford, CA, USA
D Greve - 13Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
C. G Wible - 14Department of Psychiatry, Harvard University, Boston, MA, USA
J. G Vaidya - 8Department of Psychiatry, University of Iowa, Iowa City, IA, USA
S. G Potkin - 4Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA
D. H Mathalon - 1Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA
Resource Type: Journal article
Publication Details: Psychological medicine, Vol.48(15), pp.2492-2499
DOI: 10.1017/S003329171800003X
PMID: 29444726
PMCID: PMC12094034
NLM abbreviation: Psychol Med
ISSN: 0033-2917
eISSN: 1469-8978
Publisher: Cambridge University Press; Cambridge, UK
Number of pages: 8
Language: English
Date published: 11/2018
Academic Unit: Psychiatry; Iowa Neuroscience Institute; University College Courses
Record Identifier: 9984070702502771

Metrics

20 Record Views

114 Times Cited - Web of Science

See more details