Journal article
Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis
The Journal of clinical investigation, Vol.80(6), pp.1808-1811
12/1987
DOI: 10.1172/JCI113276
PMID: 3680531
Abstract
Atherosclerosis results in impaired relaxation to acetylcholine, thrombin, and the calcium ionophore A23187, all agents that require the presence of endothelium. We now report that dietary treatment of atherosclerosis in monkeys not only produces morphological improvement of the atherosclerotic lesion but restores endothelium-dependent vascular relaxation to normal. Because the intima remains thickened after regression of atherosclerosis, these studies suggest that intimal thickening which is present in both atherosclerotic vessels and after regression of atherosclerosis does not prevent the endothelium-derived relaxing factor from reaching the underlying vascular smooth muscle.
Details
- Title: Subtitle
- Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis
- Creators
- D G Harrison - Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242M L Armstrong - Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242P C Freiman - Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242D D Heistad - Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.80(6), pp.1808-1811
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI113276
- PMID
- 3680531
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 12/1987
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040485702771
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