Journal article
Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knock-Out Mice Rescues Fear Memory But Not Unconditioned Fear Responses
The Journal of neuroscience, Vol.28(51), pp.13738-13741
12/17/2008
DOI: 10.1523/JNEUROSCI.3907-08.2008
PMID: 19091964
Abstract
Acid-sensing ion channel-1a (ASIC1a) contributes to multiple fear behaviors, however the site of ASIC1a action in behavior is not known. To explore a specific location of ASIC1a action, we expressed ASIC1a in the basolateral amygdala of ASIC1a–/– mice using viral vector-mediated gene transfer. This rescued context-dependent fear memory, but not the freezing deficit during training or the unconditioned fear response to predator odor. These data pinpoint the basolateral amygdala as the site where ASIC1a contributes to fear memory. They also discriminate fear memory from fear expressed during training and from unconditioned fear. Furthermore, this work illustrates a strategy for identifying discrete brain regions where specific genes contribute to complex behaviors.
Details
- Title: Subtitle
- Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knock-Out Mice Rescues Fear Memory But Not Unconditioned Fear Responses
- Creators
- Matthew W Coryell - Neuroscience Program andAmanda M Wunsch - PsychiatryJill M Haenfler - Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242Jason E Allen - PsychiatryJodi L McBride - Internal Medicine, andBeverly L Davidson - Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, andJohn A Wemmie - Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.28(51), pp.13738-13741
- DOI
- 10.1523/JNEUROSCI.3907-08.2008
- PMID
- 19091964
- NLM abbreviation
- J Neurosci
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Publisher
- Society for Neuroscience
- Language
- English
- Date published
- 12/17/2008
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
- Record Identifier
- 9984004084402771
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