Journal article
Restriction Endonuclease Mapping of Globin Genomic Regions of Hel (Human Erythroleukemia) Line
Hemoglobin, Vol.7(3), pp.245-256
1983
DOI: 10.3109/03630268309048653
PMID: 6307930
Abstract
The restriction endonuclease map of the alpha and beta globin genomic region of the new human erythroleukemia line, HEL, was compared with that of normal human DNA. The HEL line, which produces mainly fetal (G γ and A γ) but no adult (δ and β) globin chains, was shown to have the same pattern of DNA fragments as that of normal human DNA. This suggests that the selective expression of the gamma globin genes observed in HEL cells is not due to a major deletion or rearrangement in the -Gγ-Aγ- -β gene complex. Thus, the HEL line provides a model for studying the control of globin developmental switching in cells with structurally intact globin gene regions.
Details
- Title: Subtitle
- Restriction Endonuclease Mapping of Globin Genomic Regions of Hel (Human Erythroleukemia) Line
- Creators
- R. F Mueller - 1Divisions of Medical Genetics, Hematology University of Washington, Seattle, Washington, 98195J. C Murray - 1Divisions of Medical Genetics, Hematology University of Washington, Seattle, Washington, 98195R Gelinas - 1Divisions of Medical Genetics, Hematology University of Washington, Seattle, Washington, 98195M Farquhar - 1Divisions of Medical Genetics, Hematology University of Washington, Seattle, Washington, 98195Th Papayannopoulou - 2Fred Hutchinson Cancer Research Center, Seattle, Washington, 98104
- Resource Type
- Journal article
- Publication Details
- Hemoglobin, Vol.7(3), pp.245-256
- DOI
- 10.3109/03630268309048653
- PMID
- 6307930
- NLM abbreviation
- Hemoglobin
- ISSN
- 0363-0269
- eISSN
- 1532-432X
- Publisher
- Informa UK Ltd
- Language
- English
- Date published
- 1983
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025697302771
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