Journal article
Restriction fragment length polymorphisms associated with abnormal lipid levels in an adolescent population
Atherosclerosis, Vol.77(2), pp.227-237
1989
DOI: 10.1016/0021-9150(89)90086-5
PMID: 2751755
Abstract
The association of restriction fragment length polymorphism genetic markers at the apolipoprotein AI-CIII-AIV gene locus with lipid and lipoprotein levels was evaluated in subsets of the 666 Caucasian students from the junior high school (11–14 years old) population of Muscatine, Iowa. Male students whose leukocyte DNA had an uncommon haplotype consisting of the minor allele of a
SacI restriction site polymorphism (S2) in combination with the more common allele of an M
spI site variation (M1) had significantly lower levels of high density lipoprotein (HDL)-cholesterol (
P < 0.05) when compared to a random sample of males; these levels were stable over a 2-year follow-up. The minor allele of an
XmnI restriction site polymorphism (X2) was more frequent in females with triglyceride levels in the upper decile of the age and gender-specific triglyceride distribution than in normotriglyceridemic females (0.10 <
P < 0.15) and triglyceride levels were higher in random sample females with an X2 allele than in X1 homozygotes (
P < 0.10). These results suggest that alleles of the known apolipoprotein genes (AI, CIII, AIV) at this locus or closely linked gene sequences may have major effects on lipid levels in members of the general population.
Details
- Title: Subtitle
- Restriction fragment length polymorphisms associated with abnormal lipid levels in an adolescent population
- Creators
- Richard A. Anderson - Veterans Administration Medical Center, University of Iowa, Iowa City, IA, U.S.A.Trudy L. Burns - University of IowaJulia Lee - Department of Pediatrics, University of Iowa, Iowa City, IA, U.S.ADana Swenson - Veterans Administration Medical Center, University of Iowa, Iowa City, IA, U.S.A.Jackie L. Bristow - Veterans Administration Medical Center, University of Iowa, Iowa City, IA, U.S.A.
- Resource Type
- Journal article
- Publication Details
- Atherosclerosis, Vol.77(2), pp.227-237
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/0021-9150(89)90086-5
- PMID
- 2751755
- ISSN
- 0021-9150
- eISSN
- 1879-1484
- Language
- English
- Date published
- 1989
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364460202771
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