Journal article
Results From the Big Ten COVID-19 Cardiac Registry: Impact of SARS-COV-2 on Myocardial Involvement
Clinical journal of sport medicine, Vol.35(2), pp.152-161
03/2025
DOI: 10.1097/JSM.0000000000001247
PMID: 38975888
Abstract
Objective: COVID-19 has been associated with myocardial involvement in collegiate athletes. The first report from the Big Ten COVID-19 Cardiac Registry (Registry) was an ecological study that reported myocarditis in 37 of 1597 athletes (2.3%) based on local clinical diagnosis. Our objective was to assess the relationship between athlete and clinical characteristics and myocardial involvement. Design: Cross-sectional study. Setting: We analyzed data from 1218 COVID-19 positive Big Ten collegiate athletes who provided informed consent to participate in the Registry. Participants: 1218 athletes with a COVID-19–positive PCR test before June 1, 2021. Assessment of Independent Variables: Demographic and clinical characteristics of athletes were obtained from the medical record. Main Outcome Measures: Myocardial involvement was diagnosed based on local clinical, cardiac magnetic resonance (CMR), electrocardiography, troponin assay, and echocardiography. We assessed the association of clinical factors with myocardial involvement using logistic regression and estimated the area under the receiver operating characteristic (ROC) curve. Results: 25 of 1218 (2.0%) athletes met criteria for myocardial involvement. The logistic regression model used to predict myocardial involvement contained indicator variables for chest pain, new exercise intolerance, abnormal echocardiogram (echo), and abnormal troponin. The area under the ROC curve for these indicators was 0.714. The presence of any of these 4 factors in a collegiate athlete who tested positive for COVID-19 would capture 55.6% of cases. Among noncases without missing data, 86.9% would not be flagged for possible myocardial involvement. Conclusion: Myocardial involvement was infrequent. We predicted case status with good specificity but deficient sensitivity. A diagnostic approach for myocardial involvement based exclusively on symptoms would be less sensitive than one based on symptoms, echo, and troponin level evaluations. Abnormality of any of these evaluations would be an indication for CMR.
Details
- Title: Subtitle
- Results From the Big Ten COVID-19 Cardiac Registry: Impact of SARS-COV-2 on Myocardial Involvement
- Creators
- Jennifer S. Albrecht - University of Maryland, BaltimoreJoel T. Greenshields - Canadian Sport Institute Ontario, Toronto, CanadaSuzanne Smart - The Ohio State UniversityIan H. Law - University of IowaLarry R. Rink - Indiana University BloomingtonCurt J. Daniels - The Ohio State UniversitySaurabh Rajpal - The Ohio State UniversityEugene H. Chung - Harvard Medical SchoolJean Jeudy - University of Maryland, BaltimoreRichard Kovacs - Indiana UniversityJason Womack - Rutgers, The State University of New JerseyCarrie Esopenko - Icahn School of Medicine at Mount SinaiPhilip BoshaMichael Terrin - University of Maryland, BaltimoreGeoffrey L. Rosenthal - University of Virginia
- Resource Type
- Journal article
- Publication Details
- Clinical journal of sport medicine, Vol.35(2), pp.152-161
- DOI
- 10.1097/JSM.0000000000001247
- PMID
- 38975888
- ISSN
- 1050-642X
- eISSN
- 1536-3724
- Language
- English
- Electronic publication date
- 07/09/2024
- Date published
- 03/2025
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984656558402771
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