Journal article
Results from a Single Institution Phase II Trial of Concurrent Docetaxel/Carboplatin/Radiotherapy Followed by Surgical Resection and Consolidation Docetaxel/Carboplatin in Stage III Non-Small-Cell Lung Cancer
Clinical lung cancer, Vol.12(5), pp.280-285
09/01/2011
DOI: 10.1016/j.cllc.2011.06.003
PMID: 21752720
Abstract
Background: The optimal treatment of locally advanced non-small-cell lung cancer (NSCLC) remains controversial. We hypothesized that using a trimodality approach in selected patients with stage IIIA/IIIB disease would be both feasible and efficacious with reasonable toxicity. Patients/Methods: We enrolled 13 patients with resectable stage III NSCLC on a prospective phase II trial of trimodality therapy. Induction treatment consisted of weekly docetaxel 20 mg/m(2) and weekly carboplatin at an area under curve (AUC) of 2 concurrent with 45 Gy thoracic radiotherapy. Resection was performed unless felt to be unsafe or if patients had progressive disease. Postoperative consolidation consisted of docetaxel 75 mg/m(2) and carboplatin at an AUC of 6 every 3 weeks for 3 cycles with growth factor support. Results: All patients responded to induction chemoradiotherapy as measured by total gross tumor volume reductions of 43% on average ( range, 27%-64%). Twelve patients underwent resection of the tumor and involved nodes, yielding a resectability rate of 92%. The primary endpoint of 2-year overall survival (OS) was 72% (95% confidence interval [CI], 36%-90%), and 2-year progression-free survival (PFS) was 36% (95% CI, 9%-64%). The maximal toxicity observed per patient was grade II in 5 patients (38%); grade III in 7 patients (54%); grade IV in 1 patient (8%); and grade V in none. Conclusion: This trimodality approach resulted in promising outcomes with reasonable toxicity in carefully selected patients with stage III NSCLC at a single institution.
Details
- Title: Subtitle
- Results from a Single Institution Phase II Trial of Concurrent Docetaxel/Carboplatin/Radiotherapy Followed by Surgical Resection and Consolidation Docetaxel/Carboplatin in Stage III Non-Small-Cell Lung Cancer
- Creators
- Millie Das - Stanford UniversityJessica S. Donington - New York UniversityJames Murphy - Stanford UniversityMargaret Kozak - Stanford UniversityNeville Eclov - Stanford UniversityRichard I. Whyte - Stanford UniversityChuong D. Hoang - Stanford UniversityLisa Zhou - Stanford UniversityQuynh-Thu Le - Stanford UniversityBilly W. Loo - Stanford UniversityHeather Wakelee - Stanford University
- Resource Type
- Journal article
- Publication Details
- Clinical lung cancer, Vol.12(5), pp.280-285
- Publisher
- Cig Media Group, Lp
- DOI
- 10.1016/j.cllc.2011.06.003
- PMID
- 21752720
- ISSN
- 1525-7304
- eISSN
- 1938-0690
- Number of pages
- 6
- Grant note
- Aventis Pharmaceuticals
- Language
- English
- Date published
- 09/01/2011
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984312987202771
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