Journal article
Results of Automated Retinal Image Analysis for Detection of Diabetic Retinopathy from the Nakuru Study, Kenya
PloS one, Vol.10(10), e0139148
2015
DOI: 10.1371/journal.pone.0139148
PMCID: PMC4591009
PMID: 26425849
Abstract
Digital retinal imaging is an established method of screening for diabetic retinopathy (DR). It has been established that currently about 1% of the world's blind or visually impaired is due to DR. However, the increasing prevalence of diabetes mellitus and DR is creating an increased workload on those with expertise in grading retinal images. Safe and reliable automated analysis of retinal images may support screening services worldwide. This study aimed to compare the Iowa Detection Program (IDP) ability to detect diabetic eye diseases (DED) to human grading carried out at Moorfields Reading Centre on the population of Nakuru Study from Kenya. Retinal images were taken from participants of the Nakuru Eye Disease Study in Kenya in 2007/08 (n = 4,381 participants [NW6 Topcon Digital Retinal Camera]). First, human grading was performed for the presence or absence of DR, and for those with DR this was sub-divided in to referable or non-referable DR. The automated IDP software was deployed to identify those with DR and also to categorize the severity of DR. The primary outcomes were sensitivity, specificity, and positive and negative predictive value of IDP versus the human grader as reference standard. Altogether 3,460 participants were included. 113 had DED, giving a prevalence of 3.3% (95% CI, 2.7-3.9%). Sensitivity of the IDP to detect DED as by the human grading was 91.0% (95% CI, 88.0-93.4%). The IDP ability to detect DED gave an AUC of 0.878 (95% CI 0.850-0.905). It showed a negative predictive value of 98%. The IDP missed no vision threatening retinopathy in any patients and none of the false negative cases met criteria for treatment. In this epidemiological sample, the IDP's grading was comparable to that of human graders'. It therefore might be feasible to consider inclusion into usual epidemiological grading.
Details
- Title: Subtitle
- Results of Automated Retinal Image Analysis for Detection of Diabetic Retinopathy from the Nakuru Study, Kenya
- Creators
- Morten B Hansen - NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophtalmology, London, United Kingdom; Research Unit of Ophthalmology, University of Southern Denmark, Odense, DenmarkMichael D Abràmoff - Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, IA, 52242, United States of AmericaJames C Folk - Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, IA, 52242, United States of AmericaWanjiku Mathenge - Rwanda International Institute of Ophthalmology, P.O. Box 312, Kigali, RwandaAndrew Bastawrous - International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), London, United KingdomTunde Peto - NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophtalmology, London, United Kingdom
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.10(10), e0139148
- DOI
- 10.1371/journal.pone.0139148
- PMID
- 26425849
- PMCID
- PMC4591009
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- G1001934 / Medical Research Council Medical Research Council R01EY018853 / NEI NIH HHS R01EY017066 / NEI NIH HHS
- Language
- English
- Date published
- 2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
- Record Identifier
- 9983805901102771
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