Journal article
Results of consolidative radiotherapy for relapsed diffuse B-cell lymphoma
Reports of practical oncology and radiotherapy, Vol.28(5), pp.601-607
01/01/2023
DOI: 10.5603/rpor.96866
PMCID: PMC10764051
PMID: 38179283
Abstract
Background: Recurrent diffuse large B-cell lymphoma (DLBCL) is a disease with high mortality. The standard of care involves autologous stem-cell transplantation (ASCT), which is not always feasible. We investigated the impact of radiotherapy as part of the salvage treatment for patients with relapsed disease.
Materials and methods: retrospective study of patients with recurrent DLBCL after chemotherapy and consolidative radiotherapy at a single institution. All patients were included if radiation was part of the first treatment.
Results: Of 359 patients assessed between 2010 and 2017, 65 (18.1%) presented a recurrence, but only 62 received further treatment and were included in the study. Mean overall survival was 18.6 months since diagnosis and progression-free survival after first progression (PFS2) was 7.7 months. Patients were divided into two groups according to whether they did (24.8%) or did not (75.8%) receive radiation as part of their salvage treatment. Patients that did not receive R-CHOP (rituximab plus cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone) in the first line were treated more with radiation in the second line (p = 0.02). Six patients with in-field relapse were re-irradiated. Only 4 patients received ASCT as part of their treatment for relapsed disease. There was no difference in outcomes.
Conclusion: There is a place for radiotherapy in the treatment of relapsed DLBCL, particularly when patients do not receive ASCT. Radiotherapy is well-tolerated. More trials to assess the role of radiotherapy for these patients are needed.
Details
- Title: Subtitle
- Results of consolidative radiotherapy for relapsed diffuse B-cell lymphoma
- Creators
- Geovanne Pedro Mauro - Universidade de São PauloMario Ribeiro Neto - Universidade de São PauloHeloisa de Andrade Carvalho - Hospital Santa Paula
- Resource Type
- Journal article
- Publication Details
- Reports of practical oncology and radiotherapy, Vol.28(5), pp.601-607
- DOI
- 10.5603/rpor.96866
- PMID
- 38179283
- PMCID
- PMC10764051
- NLM abbreviation
- Rep Pract Oncol Radiother
- ISSN
- 1507-1367
- eISSN
- 2083-4640
- Publisher
- Via Medica
- Number of pages
- 7
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984914144802771
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