Results of radiotherapy for thymoma: retrospective cohort and propensity score matching analysis

Jordana de Paula Soares; Gabriel Faria Najas; Geovanne Pedro Mauro; Kennya Medeiros Lopes de Barros Lima; Clarissa Cerchi Angotti Ramos; Pedro Henrique Xavier Nabuco de Araujo; Heloisa de Andrade Carvalho

doi:10.36416/1806-3756/e20240331

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Results of radiotherapy for thymoma: retrospective cohort and propensity score matching analysis

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Results of radiotherapy for thymoma: retrospective cohort and propensity score matching analysis

Jordana de Paula Soares, Gabriel Faria Najas, Geovanne Pedro Mauro, Kennya Medeiros Lopes de Barros Lima, Clarissa Cerchi Angotti Ramos, Pedro Henrique Xavier Nabuco de Araujo and Heloisa de Andrade Carvalho

Jornal brasileiro de pneumologia, Vol.51(3), p.e20240331

2025

DOI: 10.36416/1806-3756/e20240331

PMID: 40929476

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Abstract

Thymic tumors are a rare group of anterior mediastinal tumors. Surgery is the primary treatment. Adjuvant treatment is used in select cases. The purpose of this study was to evaluate the outcomes of patients with thymic tumors, submitted or not to radiotherapy, and identify risk factors that could impact the outcomes to better support patient selection for RT. This is a single institution retrospective cohort study. Patients with histologically proven thymoma or thymic carcinoma treated from July of 2009 to November of 2020 were included. Analysis was based on the use of radiation therapy (RT). Overall survival and disease-free survival were assessed from the date of diagnosis. To minimize selection bias, propensity score matching (PSM) regression using Kernel matching was used, estimated on the population for average treatment effect. Overall, 101 patients were analyzed, with mean age at diagnosis of 54.6 years (range 25-84 years). Unfavorable histology and more advanced stages predominated in the cohort. Nevertheless, most (69.3%) were treated with radical intent. RT was delivered in 52.9% of these patients. Five-year OS, local progression and distant progression free survivals were 81.0%, 95.0% and 88.1%, respectively for the radical intent cohort. PSM showed that RT reduced the chances of death by 6.3% (matched sample size was 60, p = 0.02). In this retrospective cohort, RT had a positive impact in OS after PSM analysis. Prospective data regarding the role of RT in this disease is needed to validate these findings.

Adult

Aged

Aged, 80 and over

Disease-Free Survival

Female

Humans

Male

Middle Aged

Propensity Score

Retrospective Studies

Risk Factors

Thymoma - mortality

Thymoma - pathology

Thymoma - radiotherapy

Thymus Neoplasms - mortality

Thymus Neoplasms - pathology

Thymus Neoplasms - radiotherapy

Treatment Outcome

Details

Title: Subtitle: Results of radiotherapy for thymoma: retrospective cohort and propensity score matching analysis
Creators: Jordana de Paula Soares - Instituto do Câncer do Estado de São Paulo
Gabriel Faria Najas - Instituto do Câncer do Estado de São Paulo
Geovanne Pedro Mauro - Universidade de São Paulo
Kennya Medeiros Lopes de Barros Lima - . Departamento de Radiologia e Oncologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil
Clarissa Cerchi Angotti Ramos - Instituto do Câncer do Estado de São Paulo
Pedro Henrique Xavier Nabuco de Araujo - Instituto do Câncer do Estado de São Paulo
Heloisa de Andrade Carvalho - . Departamento de Radiologia e Oncologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil
Resource Type: Journal article
Publication Details: Jornal brasileiro de pneumologia, Vol.51(3), p.e20240331
DOI: 10.36416/1806-3756/e20240331
PMID: 40929476
NLM abbreviation: J Bras Pneumol
ISSN: 1806-3713
eISSN: 1806-3756
Language: English
Date published: 2025
Academic Unit: Radiation Oncology
Record Identifier: 9985224318102771

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