Journal article
Results of the ANSWER Trial Using the PulseRider for the Treatment of Broad-Necked, Bifurcation Aneurysms
Neurosurgery, Vol.81(1), pp.56-65
07/01/2017
DOI: 10.1093/neuros/nyx085
PMID: 28449126
Abstract
The safety and probable benefit of the PulseRider (Pulsar Vascular, Los Gatos, California) for the treatment of broad-necked, bifurcation aneurysms was studied in the context of the prospective, nonrandomized, single arm clinical trial-the Adjunctive Neurovascular Support of Wide-neck aneurysm Embolization and Reconstruction (ANSWER) Trial.
To present the results of the United States cases employing the PulseRider device as part of the ANSWER clinical trial.
Aneurysms treated with the PulseRider device among sites enrolling in the ANSWER trial were prospectively studied and the results are summarized. Aneurysms arising at either the carotid terminus or basilar apex that were relatively broad necked were considered candidates for inclusion into the ANSWER study.
Thirty-four patients were enrolled (29 female and 5 male) with a mean age of 60.9 years (27 basilar apex and 7 carotid terminus). Mean aneurysm height ranged from 2.4 to 15.9 mm with a mean neck size of 5.2 mm (range 2.3-11.6 mm). In all patients, the device was delivered and deployed. Immediate Raymond I or II occlusion was achieved in 82.4% and progressed to 87.9% at 6-month follow-up. A modified Rankin Score of 2 or less was seen in 94% of patients at 6 months.
The results from the ANSWER trial demonstrate that the PulseRider device is safe and offers probable benefit as for the treatment of bifurcation aneurysms arising at the basilar apex or carotid terminus. As such, it represents a useful addition to the armamentarium of the neuroendovascular specialist.
Details
- Title: Subtitle
- Results of the ANSWER Trial Using the PulseRider for the Treatment of Broad-Necked, Bifurcation Aneurysms
- Creators
- Alejandro M Spiotta - Department of Neurosurgery, Medical University of South Carolina, Charleston, South CarolinaColin P Derdeyn - Department of Radiology, Neurology and Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IowaSatoshi Tateshima - Department of Radiology, UCLA Medical Center, Santa Monica, Cali-forniaJay Mocco - Department of Neurosurgery, Mount Sinai Medical Center, Miami Beach, FloridaR Webster Crowley - Department of Neurosurgery, Rush University Medical Center, Chicago, IllinoisKenneth C Liu - Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, VirginiaLee Jensen - De-partment of Radiology, University of Virginia School of Medicine, Charlottesville, VirginiaKoji Ebersole - Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KansasAlan Reeves - Department of Radiology, University of Kansas Medical Center, Kansas City, KansasDemetrius K Lopes - Department of Neurosurgery, Rush University Medical Center, Chicago, IllinoisRicardo A Hanel - Department of Neurosurgery, Baptist Health, Jacksonville, FloridaEric Sauvageau - Department of Neurosurgery, Baptist Health, Jacksonville, FloridaGary Duckwiler - Department of Radiology, UCLA Medical Center, Santa Monica, Cali-forniaAdnan Siddiqui - Department of Neurosurgery, University at Buffalo, Buffalo, New YorkElad Levy - Department of Neurosurgery, University at Buffalo, Buffalo, New YorkAjit Puri - Department of Radiology, UMass Memorial Medical Cen-ter, Worcester, MassachusettsLee Pride - Department of Radiology, UT Southwestern Medical Center, Dallas, TexasRoberta Novakovic - Department of Radiology, UT Southwestern Medical Center, Dallas, TexasM Imran Chaudry - Department of Neurosurgery, Medical University of South Carolina, Charleston, South CarolinaRaymond D Turner - Department of Neurosurgery, Medical University of South Carolina, Charleston, South CarolinaAquilla S Turk - Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina
- Resource Type
- Journal article
- Publication Details
- Neurosurgery, Vol.81(1), pp.56-65
- Publisher
- United States
- DOI
- 10.1093/neuros/nyx085
- PMID
- 28449126
- ISSN
- 0148-396X
- eISSN
- 1524-4040
- Language
- English
- Date published
- 07/01/2017
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984014017402771
Metrics
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