Journal article
Results of the citalopram to enhance cognition in Huntington disease trial
Movement disorders, Vol.29(3), pp.401-405
03/2014
DOI: 10.1002/mds.25750
PMCID: PMC3960314
PMID: 24375941
Abstract
ABSTRACT
Background
The objective of this study was to evaluate citalopram for executive functioning in Huntington's disease (HD).
Methods
The study was randomized, double‐blind, and placebo‐controlled. Thirty‐three adults with HD, cognitive complaints, and no depression (Hamilton Depression [HAM‐D] rating scale ≤12) were administered citalopram 20 mg or placebo (7 visits, 20 weeks), with practice and placebo run‐ins. The primary outcome was change in executive functioning.
Results
The intent to treat analysis was controlled for practice effects, comparing visits 1 and 2 to visits 5 and 6 for citalopram versus placebo. There were no significant benefits on the executive function composite (treatment‐placebo mean difference −0.167; 95% confidence interval [CI], −0.361 to 0.028; P = .092). Citalopram participants showed improved clinician‐rated depression symptoms on the HAM‐D (t = −2.02; P = 0.05). There were no group differences on motor ratings, self‐reported executive functions, psychiatric symptoms, or functional status.
Conclusions
There was no evidence that short‐term treatment with citalopram improved executive functions in HD. Despite excluding patients with active depression, participants on citalopram showed improved mood, raising the possibility of efficacy for subsyndromal depression in HD. © 2013 International Parkinson and Movement Disorder Society
Details
- Title: Subtitle
- Results of the citalopram to enhance cognition in Huntington disease trial
- Creators
- Leigh J Beglinger - Elks Rehab HospitalWilliam H Adams - Loyola University ChicagoDouglas Langbehn - University of IowaJess G Fiedorowicz - University of IowaRicardo Jorge - University of IowaKevin Biglan - University of Rochester, RochesterJohn Caviness - Mayo Clinic ScottsdaleBlair Olson - University of IowaRobert G Robinson - University of IowaKarl Kieburtz - University of Rochester, RochesterJane S Paulsen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.29(3), pp.401-405
- DOI
- 10.1002/mds.25750
- PMID
- 24375941
- PMCID
- PMC3960314
- NLM abbreviation
- Mov Disord
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Number of pages
- 5
- Language
- English
- Date published
- 03/2014
- Academic Unit
- Psychiatry; Epidemiology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070957302771
Metrics
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