Resynchronization therapy in pediatric and congenital heart disease patients : An international multicenter study

Anne M DUBIN; Jan JANOUSEK; Andrew DAVIS; Peter P KARPAWICH; Amin AL AHMAD; Victoria L VETTER; Naomi J KERTESZ; Maully SHAH; Christopher SNYDER; Elizabeth STEPHENSON; Mathias EMMEL; Shubhayan SANATANI; Edward RHEE; Ronald KANTER; Anian BATRA; Kathrvn K COLLINS; Margaret J STRIEPER; Frank CECCHIN; Ian H LAW; Kevin M SHANNON; Joel TEMPLE; Eric ROSENTHAL; Frank J ZIMMERMAN

doi:10.1016/j.jacc.2005.05.096

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Resynchronization therapy in pediatric and congenital heart disease patients : An international multicenter study

Journal article

Open access

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Resynchronization therapy in pediatric and congenital heart disease patients : An international multicenter study

Anne M DUBIN, Jan JANOUSEK, Andrew DAVIS, Peter P KARPAWICH, Amin AL AHMAD, Victoria L VETTER, Naomi J KERTESZ, Maully SHAH, Christopher SNYDER, Elizabeth STEPHENSON, …

Journal of the American College of Cardiology, Vol.46(12), pp.2277-2283

2005

DOI: 10.1016/j.jacc.2005.05.096

PMID: 16360058

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Abstract

Objectives: Our objective was to evaluate the short-term safety and efficacy of cardiac resynchronization therapy (CRT) in children. Background: Cardiac resynchronization therapy has been beneficial for adult patients with poor left ventricular function and intraventricular conduction delay. The efficacy of this therapy in the young and in those with congenital heart disease (CHD) has not yet been established. Methods: This is a multi-center, retrospective evaluation of CRT in 103 patients from 22 institutions. Results: Median age at time of implantation was 12.8 years (3 months to 55.4 years). Median duration of follow-up was four months (22 days to 1 year). The diagnosis was CHD in 73 patients (71%), cardiomyopathy in 16 (16%), and congenital complete atrioventricular block in 14 (13%). The QRS duration before pacing was 166.1 +/- 33.3 ms, which decreased after CRT by 37.7 +/- 30.7 ms (p < 0.01). Pre-CRT systemic ventricular ejection fraction (EF) was 26.2 +/- 11.6%. The EF increased by 12.8 +/- 12.7 EF units with a mean EF after CRT of 39.9 +/- 14.8% (p < 0.05). Of 18 patients who underwent CRT while listed for heart transplantation, 3 improved sufficiently to allow removal from the transplant waiting list, 5 underwent transplant, 2 died, and 8 others are currently awaiting transplant. Conclusions: Cardiac resynchronization therapy appears to offer benefit in pediatric and CHD patients who differ substantially from the adult populations in whom this therapy has been most thoroughly evaluated to date. Further studies looking at the long-term benefit of this therapy in this population are needed.

Cardiology. Vascular system

Biological and medical sciences

Medical sciences

Details

Title: Subtitle: Resynchronization therapy in pediatric and congenital heart disease patients : An international multicenter study
Creators: Anne M DUBIN - Lucile Packard Children's Hospital, Palo Alto, California, United States
Jan JANOUSEK - University Hospital Motol, Prague, Czech Republic
Andrew DAVIS - Royal Children's Hospital, Melbourne, Australia
Peter P KARPAWICH - Children's Hospital of Michigan, Detroit, Michigan, United States
Amin AL AHMAD - Stanford University
Victoria L VETTER - Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Naomi J KERTESZ - Texas Children's Hospital, Houston, Texas, United States
Maully SHAH - Seattle Children's Hospital, Seattle, Washington, United States
Christopher SNYDER - Yale-New Haven Children's Hospital, New Haven, Connecticut, United States
Elizabeth STEPHENSON - Hospital for Sick Children, Toronto, Canada
Mathias EMMEL - University of Cologne Medical Center, Cologne, Germany
Shubhayan SANATANI - British Columbia Children's Hospital, Vancouver, Canada
Edward RHEE - St. Louis Children's Hospital, St. Louis, Missouri, United States
Ronald KANTER - Duke University Medical Center, Durham, North Carolina, United States
Anian BATRA - Riley Children's Hospital, Indianapolis, Indiana, United States
Kathrvn K COLLINS - UCSF Children's Hospital, San Francisco, California, United States
Margaret J STRIEPER - Children's Healthcare of Atlanta, Atlanta, Georgia, United States
Frank CECCHIN - Children's Hospital Boston, Boston, Massachusetts, United States
Ian H LAW - Children's Hospital of Iowa, Iowa City, Iowa, United States
Kevin M SHANNON - Mattel Children's Hospital, Los Angeles, California, United States
Joel TEMPLE - Arkansas Children's Hospital, Little Rock, Arkansas, United States
Eric ROSENTHAL - Guy's Hospital, London, United Kingdom
Frank J ZIMMERMAN - University of Chicago Children's Hospital, Chicago, Illinois, United States
Resource Type: Journal article
Publication Details: Journal of the American College of Cardiology, Vol.46(12), pp.2277-2283
Publisher: Elsevier Science
DOI: 10.1016/j.jacc.2005.05.096
PMID: 16360058
ISSN: 0735-1097
eISSN: 1558-3597
Language: English
Date published: 2005
Academic Unit: Cardiology; Stead Family Department of Pediatrics
Record Identifier: 9984093372302771

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