Journal article
Retention and extinction of delay eyeblink conditioning are modulated by central cannabinoids
Learning & memory (Cold Spring Harbor, N.Y.), Vol.18(10), pp.634-638
10/2011
DOI: 10.1101/lm.2254111
PMCID: PMC3256566
PMID: 21940395
Abstract
Rats administered the cannabinoid agonist WIN55,212-2 or the antagonist SR141716A exhibit marked deficits during acquisition of delay eyeblink conditioning, as noted by Steinmetz and Freeman in an earlier study. However, the effects of these drugs on retention and extinction of eyeblink conditioning have not been assessed. The present study examined the effects of WIN55,212-2 and SR141716A on retention and extinction of delay eyeblink conditioning in rats. Rats were given acquisition training for five daily sessions followed by one session of retention training with subcutaneous administration of 3 mg/kg of WIN55,212-2 or 5 mg/kg of SR141716A and an additional session with the vehicle. Two sessions of extinction training were then given with WIN55,212-2, SR141716A, or vehicle. Retention and extinction were impaired by WIN55,212-2, whereas SR141716A produced no deficits. The extinction deficit in rats given WIN55,212-2 was observed only during the first session, suggesting a specific impairment in short-term plasticity mechanisms. The current results and previous findings indicate that the cannabinoid system modulates cerebellar contributions to acquisition, retention, and extinction of eyeblink conditioning.
Details
- Title: Subtitle
- Retention and extinction of delay eyeblink conditioning are modulated by central cannabinoids
- Creators
- Adam B Steinmetz - Department of Psychology, The University of Iowa, Iowa City, Iowa 52242, USAJohn H Freeman - Department of Psychology, The University of Iowa, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.18(10), pp.634-638
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/lm.2254111
- PMID
- 21940395
- PMCID
- PMC3256566
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Alternative title
- Cannabinoid modulation of retention and extinction
- Language
- English
- Date published
- 10/2011
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065859502771
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