Journal article
Retention of cytosine arabinoside in mouse lung following intravenous administration in liposomes of different size
Drug metabolism and disposition, Vol.7(3), pp.124-128
05/01/1979
DOI: 10.1016/S0022-5347(24)06107-X
PMID: 38080
Abstract
An extrusion technique was used to obtain multilamellar lipid vesicles (MLV, liposomes) of different size distribution. The larger MLV ranged in diameter from 0.1 to 2.6 mu and the smaller from 0.1 to 1.5 mu, and both were composed of phosphatidylserine/phosphatidylcholine/cholesterol in the molar ratio 1:4:5. After intravenous injection of large and small MLV containing encapsulated [3H]cytosine arabinoside (ara-C), their distribution in various organs showed that the fraction of the dose associated with lung was greater for large MLV relative to small MLV by factors of 3.6--10 after 1 hr, 5.3--14 after 4 hr, and 17--23 after 24 hr. For large MLV more than 50% of drug remaining in vivo after 24 hr was associated with the lung, compared with 2.5% for small MLV. Almost all of the 3H associated with lung at all times for both large and small MLV could be accounted for by unchanged ara-C. Differences in 3H levels between small and large MLV in other tissues were much less dramatic or were not significant. The apparent in vivo stability of the liposomes was not affected by size. The data are consistent with an initial trapping of large MLV during first passage in the lung, with subsequent binding and retention. Release of ara-C from large or small MLV in the lung is apparently slow relative to meatbolism.
Details
- Title: Subtitle
- Retention of cytosine arabinoside in mouse lung following intravenous administration in liposomes of different size
- Creators
- C Anthony HuntY M RustumE MayhewD Papahadjopoulos
- Resource Type
- Journal article
- Publication Details
- Drug metabolism and disposition, Vol.7(3), pp.124-128
- DOI
- 10.1016/S0022-5347(24)06107-X
- PMID
- 38080
- ISSN
- 0090-9556
- eISSN
- 1521-009X
- Language
- English
- Date published
- 05/01/1979
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359870002771
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