Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke

Baruc Campos; Hoseok Choi; Andrew T. DeMarco; Anna Seydell-Greenwald; Sara J. Hussain; Mary T. Joy; Peter E. Turkeltaub; William Zeiger

doi:10.1523/JNEUROSCI.1425-23.2023

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Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke

Journal article

Open access

Peer reviewed

Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke

Baruc Campos, Hoseok Choi, Andrew T. DeMarco, Anna Seydell-Greenwald, Sara J. Hussain, Mary T. Joy, Peter E. Turkeltaub and William Zeiger

The Journal of neuroscience, Vol.43(45), pp.7489-7500

11/08/2023

DOI: 10.1523/JNEUROSCI.1425-23.2023

PMCID: PMC10634578

PMID: 37940595

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Abstract

Stroke is one of the most common causes of disability, and there are few treatments that can improve recovery after stroke. Therapeutic development has been hindered because of a lack of understanding of precisely how neural circuits are affected by stroke, and how these circuits change to mediate recovery. Indeed, some of the hypotheses for how the CNS changes to mediate recovery, including remapping, redundancy, and diaschisis, date to more than a century ago. Recent technological advances have enabled the interrogation of neural circuits with ever greater temporal and spatial resolution. These techniques are increasingly being applied across animal models of stroke and to human stroke survivors, and are shedding light on the molecular, structural, and functional changes that neural circuits undergo after stroke. Here we review these studies and highlight important mechanisms that underlie impairment and recovery after stroke. We begin by summarizing knowledge about changes in neural activity that occur in the peri-infarct cortex, specifically considering evidence for the functional remapping hypothesis of recovery. Next, we describe the importance of neural population dynamics, disruptions in these dynamics after stroke, and how allocation of neurons into spared circuits can restore functionality. On a more global scale, we then discuss how effects on long-range pathways, including interhemispheric interactions and corticospinal tract transmission, contribute to post-stroke impairments. Finally, we look forward and consider how a deeper understanding of neural circuit mechanisms of recovery may lead to novel treatments to reduce disability and improve recovery after stroke.

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Details

Title: Subtitle: Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke
Creators: Baruc Campos - University of California, Los Angeles
Hoseok Choi - University of California, San Francisco
Andrew T. DeMarco - Georgetown University Medical Center
Anna Seydell-Greenwald - MedStar National Rehabilitation Hospital
Sara J. Hussain - The University of Texas at Austin
Mary T. Joy - Jackson Laboratory
Peter E. Turkeltaub - MedStar National Rehabilitation Hospital
William Zeiger - University of California, Los Angeles
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.43(45), pp.7489-7500
DOI: 10.1523/JNEUROSCI.1425-23.2023
PMID: 37940595
PMCID: PMC10634578
NLM abbreviation: J Neurosci
ISSN: 0270-6474
eISSN: 1529-2401
Publisher: Society for Neuroscience
Number of pages: 12
Grant note: NRTS 2199 / ; 2021R1A6A3A14045108 / ; R00DC018828; R01DC014960 / ; R01HD105735; K12HD093427 / ; 1K08NS114165-01A1 / ;
Language: English
Date published: 11/08/2023
Academic Unit: Health, Sport, and Human Physiology
Record Identifier: 9984948046702771

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