Journal article
Reticular Pseudodrusen Characteristics and Associations in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2), an Ancillary Study of the Women's Health Initiative
Ophthalmology retina, Vol.5(8), pp.721-729
08/2021
DOI: 10.1016/j.oret.2020.12.019
PMCID: PMC8243566
PMID: 33387684
Abstract
To determine the prevalence and morphologic features of reticular pseudodrusen (RPD) and their association with participant demographics and age-related macular degeneration (AMD) status in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2) sample, an ancillary study of the Women's Health Initiative Observational Study.
Cross-sectional, multicenter, natural history study.
Nine hundred and twenty-seven eyes from 466 postmenopausal women 69 to 101 years of age.
Multimodal imaging, including spectral-domain (SD) OCT and infrared reflectance (IR), were used to identify RPD characteristics, including location (within or outside the 6-mm diameter circle centered at the macula), presence of peripapillary RPD, pattern of RPD, and RPD area. Age-related macular degeneration features from SD OCT, IR, and color photographs also were assessed and AMD severity was categorized.
Reticular pseudodrusen prevalence using SD OCT and IR imaging and AMD status.
Reticular pseudodrusen were present in 130 eyes (14% of eyes, 16% of participants), with increasing prevalence with age: 7% in those younger than 78 years, 14% in those 78 to 83 years of age, and 30% in those older than 83 years. Using clinical classification of AMD with color photography, RPD were seen in 2.4% of eyes with no AMD or aging changes, 11.5% in early AMD, 25.1% in intermediate AMD, and 51.1% in late AMD. Mean RPD area was 17.4 mm
(standard deviation, 14.7 mm
). Ribbon morphologic RPD (53%) was more common than dot morphologic RPD (36%). Reticular pseudodrusen mostly were located both within and outside the 6-mm circle with primarily superior retinal distribution. Reticular pseudodrusen were visualized with corresponding color fundus photography in only 38 eyes (4% of total eyes). Participants with and without RPD had a visual acuity±standard error of 77.9 ± 1.4 letters and 81.3 ± 0.4 letters, respectively (P = 0.02).
The prevalence of RPD in CAREDS2 increased with age and was associated with AMD severity. Reticular pseudodrusen were detected in eyes without other features of AMD and could represent an earlier disease state. Multimodal imaging with SD OCT and IR has significantly greater sensitivity for visualizing RPD than color fundus photography.
Details
- Title: Subtitle
- Reticular Pseudodrusen Characteristics and Associations in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2), an Ancillary Study of the Women's Health Initiative
- Creators
- Spencer C Cleland - University of Wisconsin–MadisonAmitha Domalpally - University of Wisconsin–MadisonZhe Liu - University of Wisconsin–MadisonJeong W Pak - University of Wisconsin–MadisonBarbara A Blodi - University of Wisconsin–MadisonSteven Bailey - Oregon Health & Science UniversityKaren Gehrs - University of IowaRobert Wallace - University of IowaLesley Tinker - Fred Hutch Cancer CenterJulie A Mares - University of Wisconsin–MadisonSecond Carotenoids in Age-Related Eye Disease Study Investigators
- Contributors
- Jennifer Robinson (Contributor) - University of Iowa, Fraternal Order of Eagles Diabetes Research Center
- Resource Type
- Journal article
- Publication Details
- Ophthalmology retina, Vol.5(8), pp.721-729
- DOI
- 10.1016/j.oret.2020.12.019
- PMID
- 33387684
- PMCID
- PMC8243566
- NLM abbreviation
- Ophthalmol Retina
- ISSN
- 2468-6530
- eISSN
- 2468-6530
- Grant note
- N01WH22110 / WHI NIH HHS U10 EY013018 / NEI NIH HHS P30 EY016665 / NEI NIH HHS R01 EY016886 / NEI NIH HHS R01 EY025292 / NEI NIH HHS UL1 TR002373 / NCATS NIH HHS
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984363605402771
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