Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults

Raeda T Al-Ghananim; Demet Nalbant; Robert L Schmidt; Gretchen A Cress; M Bridget Zimmerman; John A Widness

doi:10.1002/jcla.21859

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Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults

Journal article

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Peer reviewed

Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults

Raeda T Al-Ghananim, Demet Nalbant, Robert L Schmidt, Gretchen A Cress, M Bridget Zimmerman and John A Widness

Journal of clinical laboratory analysis, Vol.30(4), pp.326-334

07/2016

DOI: 10.1002/jcla.21859

PMCID: PMC4644110

PMID: 25968472

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Abstract

Reticulocyte hemoglobin content (RET-He)-an established indicator of iron status in children and adults-was determined in very low birth weight (VLBW) infants. Longitudinal retrospective RET-He data in 26 VLBW neonates during the first month of age were compared with: (a) concurrent complete blood counts (CBCs), including hemoglobin (Hb) concentration, reticulocyte count, and immature reticulocyte fraction (IRF), and erythropoietin (EPO) levels; (b) clinical variables; and (c) RET-He data from the literature for term infants, children, and adults. RET-He within 24 hr following birth was 31.8 ± 1.1 pg (mean ± SEM). This was followed by an abrupt, significant decline to 28.3 ± 1.1 pg at 2-4 days, and to steady state levels of 28.4 ± 0.5 pg thereafter. The changes in RET-He were mirrored by changes in plasma EPO, reticulocyte count, and IRF, but not Hb. Steady state RET-He values after 4 days were significantly lower than RET-He values for term infants, children, and adults (31.6 ± 0.11, 32.0 ± 0.12, and 33.0 ± 0.13 pg, respectively). Although RET-He values in VLBW infant were lower than term infants, children, and adults, the significance and mechanism(s) responsible are unknown. The present VLBW infant data are relevant to investigations assessing hemoglobinization following treatment with recombinant human EPO (r-HuEPO) and/or iron.

Erythropoiesis

Ferritins - blood

Humans

Critical Illness

Adult

Female

Male

Reticulocytes - metabolism

Child

Hemoglobins - analysis

Infant, Newborn

Infant, Very Low Birth Weight - blood

Details

Title: Subtitle: Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults
Creators: Raeda T Al-Ghananim - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa
Demet Nalbant - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa
Robert L Schmidt - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa
Gretchen A Cress - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa
M Bridget Zimmerman - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa
John A Widness - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Journal of clinical laboratory analysis, Vol.30(4), pp.326-334
DOI: 10.1002/jcla.21859
PMID: 25968472
PMCID: PMC4644110
NLM abbreviation: J Clin Lab Anal
ISSN: 0887-8013
eISSN: 1098-2825
Publisher: United States
Grant note: P01 HL046925 / NHLBI NIH HHS UL1 RR024979 / NCRR NIH HHS
Language: English
Date published: 07/2016
Academic Unit: Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9983997459602771

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