Journal article
Retinal Sublayer Analysis in Autoimmune Retinopathy and Identification of New Optical Coherence Tomography Phenotypes
Ocular immunology and inflammation, Vol.32(5), pp.727-734
07/2024
DOI: 10.1080/09273948.2023.2199334
PMID: 37084288
Abstract
Autoimmune retinopathy (AIR) is a poorly characterized disease with a wide phenotypic spectrum, complicating investigations of its underlying pathophysiology. We sought to analyze optical coherence tomography (OCT) retinal thickness changes in AIR patients.
A retrospective chart review from 2007 to 2017 was performed evaluating AIR patients at a single academic, tertiary referral center. OCT retinal sublayer analysis was performed, and paradoxical thickening phenotypes were reviewed.
Twenty-nine AIR patients with positive anti-retinal antibodies and OCT imaging were identified. Overall, AIR patients had thinner retinal sublayers compared to controls; however, 12 patients (41.4%) had paradoxical thickening of the outer plexiform layer (OPL). This revealed two distinct OCT phenotypes. No association was found between retinal sublayer thickness and specific antiretinal antibodies.
While the pathogenicity of antiretinal antibodies remains unclear, the OCT phenotypes observed underscore the potential for identifying clues in the underlying disease processes and clinical diagnosis.
Details
- Title: Subtitle
- Retinal Sublayer Analysis in Autoimmune Retinopathy and Identification of New Optical Coherence Tomography Phenotypes
- Creators
- Christopher R Fortenbach - University of IowaS Scott Whitmore - University of IowaMatthew J Thurtell - University of IowaElliott H Sohn - University of IowaD Brice Critser - University of IowaEdwin M Stone - University of IowaJames C Folk - University of IowaIan C Han - University of IowaTimothy M Boyce - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Ocular immunology and inflammation, Vol.32(5), pp.727-734
- DOI
- 10.1080/09273948.2023.2199334
- PMID
- 37084288
- NLM abbreviation
- Ocul Immunol Inflamm
- ISSN
- 0927-3948
- eISSN
- 1744-5078
- Grant note
- DOI: 10.13039/100008893, name: University of Iowa, award: P30 EY025580
- Language
- English
- Electronic publication date
- 04/21/2023
- Date published
- 07/2024
- Academic Unit
- Neurology; The University of Iowa Institute for Vision Research; Iowa Neuroscience Institute; John and Marcia Carver Nonprofit Genetic Testing Laboratory; Fraternal Order of Eagles Diabetes Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984398212002771
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