Journal article
Retinal Thickness and Microvascular Changes in Children With Sickle Cell Disease Evaluated by Optical Coherence Tomography (OCT) and OCT Angiography
American journal of ophthalmology, Vol.209, pp.88-98
01/2020
DOI: 10.1016/j.ajo.2019.08.019
PMID: 31473216
Abstract
To compare the severity of macular vascular changes in children with sickle cell disease (SCD) vs age- and race-matched controls.
Cross-sectional study.
Children (<18 years old) with HbSS and HbS variant (HbSC and HbS thalassemia) genotypes, and their age- and race-matched controls, were recruited between January 2017 and December 2018. All subjects underwent optical coherence tomography angiography (OCTA) scans centered on the fovea and temporal macula. Retinal thickness, superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD), and foveal avascular zone (FAZ) size were measured and compared between HbSS and HbS variant vs controls.
Thirty-four HbSS, 34 HbS variant (Goldberg staging 0-3 for SCD eyes), and 24 control eyes (total 48 children, aged 5-17 years) were included. Total VD (3-mm ETDRS circle) was lower in HbS variant eyes than in controls for both the SCP (42.9% vs 47.7%, P = .02) and DCP (47.4% vs 52.6%, P = .01). In HbSS eyes, VD was lower in the DCP (47.7%, P = .008) but not in the SCP (45.5%, P = .5), compared to controls. A higher proportion of HbSS (n = 18, 55%) than HbS variant eyes (n = 9, 26%) had pathologic areas of retinal thinning associated with SCP and DCP flow loss (P = .03). However, retinal thickness measurements and FAZ size did not differ between either HbSS or HbS variant group vs controls.
Children with SCD have similar retinal thickness but less dense vasculature on OCTA compared to age and race-matched controls, suggesting that microvascular insult may precede structural thinning.
Details
- Title: Subtitle
- Retinal Thickness and Microvascular Changes in Children With Sickle Cell Disease Evaluated by Optical Coherence Tomography (OCT) and OCT Angiography
- Creators
- Sally S Ong - Johns Hopkins University School of MedicineMarguerite O Linz - Johns Hopkins University School of MedicineXimin Li - Johns Hopkins UniversityT Y Alvin Liu - Johns Hopkins University School of MedicineIan C Han - University of IowaAdrienne W Scott - Johns Hopkins University School of Medicine
- Resource Type
- Journal article
- Publication Details
- American journal of ophthalmology, Vol.209, pp.88-98
- DOI
- 10.1016/j.ajo.2019.08.019
- PMID
- 31473216
- ISSN
- 0002-9394
- eISSN
- 1879-1891
- Grant note
- name: Johns Hopkins University Retina Division
- Language
- English
- Date published
- 01/2020
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984181080702771
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