Journal article
Retinal Vascular Caliber Changes After Topical Nepafenac Treatment for Diabetic Macular Edema
Current eye research, Vol.43(3), pp.357-361
03/04/2018
DOI: 10.1080/02713683.2017.1399425
PMID: 29120250
Abstract
Purpose: To assess changes in retinal vascular caliber in response to short-term use of nepafenac eye drops in patients with mild diabetic macular edema.
Materials and methods: Thirty-four patients with previously untreated bilateral mild diabetic macular edema were included in this prospective study. For each participant, one eye was randomly assigned to nepafenac treatment (0.1%, three times/day) and the other eye was left untreated throughout the study. Using digital fundus photographs, retinal vascular calibers were calculated and compared in treated and untreated eyes at the baseline, week 1, and week 6.
Results: Baseline vessel diameters did not differ in treated and fellow eyes (p > 0.05). Over the 6 weeks of the study, significant vasoconstriction of the retinal arteriolar caliber was observed at weeks 1 (p < 0.05) and 6 (p < 0.05), while an unchanged retinal venular caliber was noted between the treated and untreated eyes (p > 0.44). Significant macular thickness difference was only observed at week 6 (p = 0.002).
Conclusions: Topical nepafenac has a significant narrowing effect on the retinal arteriolar diameter and a significant reductive effect on central macular thickness in eyes with mild diabetic retinopathy.
Details
- Title: Subtitle
- Retinal Vascular Caliber Changes After Topical Nepafenac Treatment for Diabetic Macular Edema
- Creators
- Ferhat Evliyaoğlu - Okmeydanı Eğitim ve Araştırma HastanesiÇetin Akpolat - Okmeydanı Eğitim ve Araştırma HastanesiMuhammed Mustafa Kurt - Okmeydanı Eğitim ve Araştırma HastanesiOsman Çekiç - Department of Ophthalmology, Okmeydanı Training and Research HospitalMustafa Nuri Elcioglu - Department of Ophthalmology, Okmeydanı Training and Research Hospital
- Resource Type
- Journal article
- Publication Details
- Current eye research, Vol.43(3), pp.357-361
- DOI
- 10.1080/02713683.2017.1399425
- PMID
- 29120250
- NLM abbreviation
- Curr Eye Res
- ISSN
- 0271-3683
- eISSN
- 1460-2202
- Publisher
- Taylor & Francis
- Number of pages
- 5
- Language
- English
- Date published
- 03/04/2018
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984845397602771
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