Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies

Markus H Kuehn; John H Fingert; Young H Kwon

doi:10.1016/j.ohc.2005.04.002

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Journal article

Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies

Markus H Kuehn, John H Fingert and Young H Kwon

Ophthalmology clinics of North America, Vol.18(3), pp.383-395

09/2005

DOI: 10.1016/j.ohc.2005.04.002

PMID: 16054996

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Abstract

Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.

Glaucoma - etiology

Neuroprotective Agents - therapeutic use

Glaucoma - prevention & control

Humans

Apoptosis

Retinal Ganglion Cells - pathology

Details

Title: Subtitle: Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies
Creators: Markus H Kuehn - Department of Ophthalmology and Visual Sciences, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242, USA
John H Fingert
Young H Kwon
Resource Type: Journal article
Publication Details: Ophthalmology clinics of North America, Vol.18(3), pp.383-395
DOI: 10.1016/j.ohc.2005.04.002
PMID: 16054996
NLM abbreviation: Ophthalmol Clin North Am
ISSN: 0896-1549
eISSN: 1558-3856
Publisher: United States
Language: English
Date published: 09/2005
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980395602771

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