Retinal ganglion cell layer thinning within one month of presentation for optic neuritis

Mark J Kupersmith; Mona K Garvin; Jui-Kai Wang; Mary Durbin; Randy Kardon

doi:10.1177/1352458515598020

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Retinal ganglion cell layer thinning within one month of presentation for optic neuritis

Journal article

Open access

Peer reviewed

Retinal ganglion cell layer thinning within one month of presentation for optic neuritis

Mark J Kupersmith, Mona K Garvin, Jui-Kai Wang, Mary Durbin and Randy Kardon

Multiple sclerosis, Vol.22(5), pp.641-648

04/2016

DOI: 10.1177/1352458515598020

PMCID: PMC5300035

PMID: 26362894

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Abstract

Spectral domain optical coherence tomography (SD-OCT) reveals retinal ganglion cell layer plus inner plexiform layer (GCL+IPL) and peripapillary retinal nerve fiber layer (pRNFL) thinning in chronic optic nerve injury. At presentation, swelling of the pRNFL confounds evaluation of early axon loss. We studied whether the GCL+IPL thins before the pRNFL, the trajectory of GCL+IPL loss and relationship to vision. We prospectively evaluated 33 eyes (study) with new optic neuritis, using perimetry and SD-OCT with investigative three-dimensional layer segmentation and commercial two-dimensional segmentation to compute the GCL+IPL and pRNFL thickness. At presentation, GCL+IPL thickness (82.4±8.8 µm) did not differ from unaffected fellow eyes (81.2±6.7 µm), via the three-dimensional method, while the two-dimensional method failed in 9% of study eyes. At 1-2 months, there was thinning of the pRNFL in 10% and of the GCL+IPL in 93% of study eyes. GCL+IPL reduction was greatest during the first 2 months. GCL+IPL thinning at 1-2 months correlated with GCL+IPL thinning at 6 months (r=0.84, P=0.01) and presentation visual acuity (r=0.48, P=0.006) and perimetric mean deviation (r=0.52, P=0.003). GGL+IPL is an early biomarker of structural injury in optic neuritis as thinning develops within 1-2 months of onset, prior to pRNFL thinning.

Prospective Studies

Time Factors

Optic Neuritis - physiopathology

Humans

Optic Neuritis - diagnostic imaging

Adult

Optic Neuritis - pathology

Tomography, Optical Coherence - methods

Visual Acuity

Retina - pathology

Retinal Ganglion Cells - pathology

Details

Title: Subtitle: Retinal ganglion cell layer thinning within one month of presentation for optic neuritis
Creators: Mark J Kupersmith - New York Eye and Ear Infirmary, Mount Sinai Roosevelt Hospital, New York, USA mkuper@chpnet.org
Mona K Garvin - Department of Electrical and Computer Engineering, University of Iowa, Iowa, USA/Department of Ophthalmology, Iowa University School of Medicine and Center for Prevention and Treatment of Visual Loss, Iowa, USA
Jui-Kai Wang - Department of Electrical and Computer Engineering, University of Iowa, Iowa, USA
Mary Durbin - Carl Zeiss-Meditec, Inc., Dublin, CA
Randy Kardon - Department of Ophthalmology, Iowa University School of Medicine and Center for Prevention and Treatment of Visual Loss, Iowa, USA
Resource Type: Journal article
Publication Details: Multiple sclerosis, Vol.22(5), pp.641-648
DOI: 10.1177/1352458515598020
PMID: 26362894
PMCID: PMC5300035
NLM abbreviation: Mult Scler
ISSN: 1477-0970
eISSN: 1477-0970
Publisher: England
Grant note: R01 EY023279 / NEI NIH HHS U10 EY017281 / NEI NIH HHS R009040554 / PHS HHS IK2 RX000728 / RRD VA R01 EY018853 / NEI NIH HHS 3U10EY017281-04AS1 / ASC OASH HHS NEI R01 EY018853 / NEI NIH HHS
Language: English
Date published: 04/2016
Academic Unit: Electrical and Computer Engineering; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980077202771

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