Retinoblastoma in a dog

N A Syed; T M Nork; G L Poulsen; R C Riis; C George; D M Albert

doi:10.1001/archopht.1997.01100150760012

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Journal article

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Retinoblastoma in a dog

N A Syed, T M Nork, G L Poulsen, R C Riis, C George and D M Albert

Archives of ophthalmology (1960), Vol.115(6), pp.758-763

06/1997

DOI: 10.1001/archopht.1997.01100150760012

PMID: 9194728

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Abstract

To describe and classify a retinal tumor found in a dog that histologically resembles human retinoblastoma and to discuss the molecular mechanisms of retinal oncogenesis. A dog eye with a retinal tumor was examined histologically. Studies including immunocytochemical analysis for retinal S-antigen and glial fibrillary acidic protein, enzyme histochemical analysis for carbonic anhydrase, and nick-end DNA labeling were used to characterize the tumor. Normal retina from another dog and other tumors from dogs, including 2 ciliary body medulloepitheliomas and a brain medulloepithelioma, were examined as controls. The retinal tumor disclosed characteristics typical of human retinoblastoma, including Flexner-Wintersteiner rosettes. It showed strong immunoreactivity with S-antigen and glial fibrillary acidic protein. Carbonic anhydrase activity also could be shown in the tumor. Apoptosis was found to be the predominant method of cell death as shown by nick-end DNA labeling. In contrast to the other tumors examined, this tumor contained areas with retinal photoreceptor and glial differentiation. The histopathologic findings and differential staining characteristics in this retinal tumor are compatible with retinoblastoma, making this, to our knowledge, the first documented case of spontaneous retinoblastoma in an animal.

Immunohistochemistry

Animals

Dog Diseases - metabolism

Dogs

Eye Neoplasms - metabolism

Eye Neoplasms - pathology

Eye Neoplasms - veterinary

Male

Retinoblastoma - metabolism

Retinoblastoma - pathology

Retinoblastoma - veterinary

Dog Diseases - pathology

Details

Title: Subtitle: Retinoblastoma in a dog
Creators: N A Syed - Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
T M Nork
G L Poulsen
R C Riis
C George
D M Albert
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.115(6), pp.758-763
DOI: 10.1001/archopht.1997.01100150760012
PMID: 9194728
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Grant note: EY01917 / NEI NIH HHS EY08724 / NEI NIH HHS
Language: English
Date published: 06/1997
Academic Unit: Pathology; Ophthalmology and Visual Sciences
Record Identifier: 9983980015902771

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