Journal article
Retinoic acid affects the organization of reticulospinal neurons in developing Xenopus
Neuroscience letters, Vol.139(2), pp.253-256
1992
DOI: 10.1016/0304-3940(92)90565-O
PMID: 1608555
Abstract
The effects of all-trans retinoic acid (RA) on the differentiation of the reticulospinal system were studied in
Xenopus. RA was applied in concentrations of 10
−5 and 10
−6 M for 30 min at stage 12. When siblings had reached stages 46–48, the spinal cord was transected in anesthetized control and experimental animals and the reticulospinal cells were visualized through retrograde transport of fluorescing dextran amines. The lower concentration of RA led in many animals (22%) to the formation of multiple Mauthner-like cells. Higher concentrations resulted in the formation of two uninterrupted longitudinal columns of rather uniform reticulospinal cells. These data suggest that the normal expression of
Hox genes pattern—known to be altered by RA—may be necessary for the differential specification of compartments of the reticulospinal system.
Details
- Title: Subtitle
- Retinoic acid affects the organization of reticulospinal neurons in developing Xenopus
- Creators
- Martina MannsBernd Fritzsch
- Resource Type
- Journal article
- Publication Details
- Neuroscience letters, Vol.139(2), pp.253-256
- DOI
- 10.1016/0304-3940(92)90565-O
- PMID
- 1608555
- NLM abbreviation
- Neurosci Lett
- ISSN
- 0304-3940
- eISSN
- 1872-7972
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 1992
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070164702771
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