Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo

YiPing Chen; Li Huang; Andrew F Russo; Michael Solursh

doi:10.1073/pnas.89.21.10056

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Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo

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Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo

YiPing Chen, Li Huang, Andrew F Russo and Michael Solursh

Proceedings of the National Academy of Sciences - PNAS, Vol.89(21), pp.10056-10059

11/01/1992

DOI: 10.1073/pnas.89.21.10056

PMID: 1438194

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Abstract

Retinoic acid (RA) has been considered as a potential morphogen in the chicken limb and has also been suggested to be involved in early embryonic development. On the basis of biological activity, previous reports suggest that Hensen's node, the anatomical equivalent in the chicken of the Spemann's organizer, may contain RA. Here, by using a molecular assay system, we demonstrate that Hensen's node contains retinoids in a concentration approximately 20 times more than that in the neighboring tissues. Furthermore, stage 6 Hensen's node contains approximately 3 times more retinoid than that of stage 4 embryos. These endogenous retinoids may establish a concentration gradient from Hensen's node to adjacent tissues and play a role in establishing the primary embryonic axis in the vertebrate. The results also suggest that the retinoid concentration in Hensen's node is developmentally regulated.

Details

Title: Subtitle: Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo
Creators: YiPing Chen - Department of Biology, University of Iowa, Iowa City 52242
Li Huang - Department of Biology, University of Iowa, Iowa City 52242
Andrew F Russo - Department of Biology, University of Iowa, Iowa City 52242
Michael Solursh - Department of Biology, University of Iowa, Iowa City 52242
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.89(21), pp.10056-10059
DOI: 10.1073/pnas.89.21.10056
PMID: 1438194
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 11/01/1992
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
Record Identifier: 9984020778902771

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